Results 101 to 110 of about 869,733 (343)

Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

Advanced Functional Materials, EarlyView.
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput, Yen‐Ting Tung, Yu‐Chi Chen, Min Jae Song, Marc Ferrer, Emily M. Lee   +5 more
wiley   +1 more source

Transplantation of hearts from SARS‐CoV‐2 positive donors

ESC Heart Failure, 2023
Incidence of SARS‐CoV‐2 remains high in the population. Consequently, an increasing percentage of reported organ donors are also SARS‐CoV‐2 positive.
Payam Akhyari, Moritz Benjamin Immohr, Florian Bönner, Petra Reinecke, Artur Lichtenberg, Udo Boeken   +5 more
doaj   +1 more source

SARS-CoV-2 Infection in Children

New England Journal of Medicine, 2020
SARS-CoV-2 Infection in Children In this report, investigators in Wuhan, China, describe the spectrum of Covid-19 illness in children under the age of 16 years.
Xiaoxia Lu, Liqiong Zhang, H. Du, Jingjing Zhang, Yuan Li, Jingyu Qu, Wenxin Zhang, Youjie Wang, Shuangshuang Bao, Ying Li, Chuansha Wu, Hongxiu Liu, Di Liu, J. Shao, Xuehua Peng, Yonghong Yang, Zhi-sheng Liu, Yun Xiang, Furong Zhang, Rona M. Silva, K. Pinkerton, K. Shen, Han Xiao, Shunqing Xu, G. Wong   +24 more
semanticscholar   +1 more source

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)

Science, 2020
Undetected cases The virus causing coronavirus disease 2019 (COVID-19) has now become pandemic. How has it managed to spread from China to all around the world within 3 to 4 months? Li et al.
Ruiyun Li, S. Pei, Bin Chen, Yimeng Song, Tao Zhang, Wan Yang, J. Shaman   +6 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Sarcoidosis following SARS‐CoV‐2 infection: Cause or consequence?

Respirology Case Reports, 2022
The COVID‐19 pandemic has been a worldwide medical challenge. Despite rapid advancements, many questions regarding SARS‐CoV‐2 interaction with other pathologies and long‐term consequences remained unanswered. Sarcoidosis is a multi‐systemic granulomatous
Esther Palones, Virginia Pajares, Laura López, Diego Castillo, Alfons Torrego   +4 more
doaj   +1 more source

CRISPR-Cas12–based detection of SARS-CoV-2

Nature Biotechnology, 2020
An outbreak of betacoronavirus severe acute respiratory syndrome (SARS)-CoV-2 began in Wuhan, China in December 2019. COVID-19, the disease associated with SARS-CoV-2 infection, rapidly spread to produce a global pandemic.
James P. Broughton, Xianding Deng, Guixia Yu, C. Fasching, V. Servellita, J. Singh, X. Miao, J. Streithorst, A. Granados, A. Sotomayor-González, K. Zorn, Allan Gopez, Elaine D. Hsu, W. Gu, Steve Miller, C. Pan, H. Guevara, D. Wadford, Janice S. Chen, C. Chiu   +19 more
semanticscholar   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Infección por SARS-COV-2 en trabajadores de la salud: análisis de riesgo epidemiológico en una institución de alta complejidad de Bogotá, Colombia, 2020

Infectio, 2022
Objective: To determine the incidence of SARS-CoV-2 infection and its association with sociodemographic, clinical, and occupational characteristics in health workers (HCWs) in the COVID-19 risk area.Material and method: Longitudinal analytical study in a
Milcíades Ibáñez-Pinilla
doaj   +1 more source