Results 101 to 110 of about 1,252,032 (378)

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

New England Journal of Medicine, 2020
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and spread globally, prompting an international effort to accelerate development of a vaccine.
L. Jackson, E. Anderson, N. Rouphael, P. Roberts, M. Makhene, R. Coler, M. P. McCullough, J. Chappell, M. Denison, Laura J. Stevens, A. Pruijssers, A. McDermott, B. Flach, N. Doria-Rose, Kizzmekia S. Corbett, Kaitlyn M. Morabito, S. O'dell, S. Schmidt, P. Swanson, M. Padilla, J. Mascola, K. Neuzil, H. Bennett, Wellington Sun, E. Peters, M. Makowski, J. Albert, Kaitlyn A. Cross, Wendy L. Buchanan, Rhonda Pikaart-Tautges, J. Ledgerwood, B. Graham, J. Beigel   +32 more
semanticscholar   +1 more source

Tractament farmacològic de la infecció per SARSCoV-2: recomanacions de tractament farmacològic de pacients adults amb infecció per SARS-CoV-2 a l’àmbit SISCAT [PDF]

, 2021
Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Pacients adults; Tractament farmacològic; SISCAT; Assaigs clínicsCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Pacientes adultos; Tratamiento farmacológico; SISCAT; Ensayos clínicosCoronavirus SARS-CoV-2; COVID-
Comissió Assessora per al Tractament Farmacològic de la Infecció per SARS-CoV-2
core   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Susceptibility of lung cancer patients to COVID‐19: A review of the pandemic data from multiple nationalities

Thoracic Cancer, 2021
Several studies have highlighted that cancer patients tend to be more susceptible to develop severe infection and to die from COVID‐19. Certain medical conditions such as immunosuppression, presence of comorbidities, and underlying pulmonary damage are ...
Ana Emília Goulart Lemos, Gabriela Ribeiro Silva, Etel Rodrigues Pereira Gimba, Aline da Rocha Matos   +3 more
doaj   +1 more source

Detection of a SARS-CoV-2 variant of concern in South Africa

Nature, 2021
Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2.
H. Tegally, E. Wilkinson, M. Giovanetti, A. Iranzadeh, V. Fonseca, J. Giandhari, D. Doolabh, S. Pillay, E. J. San, N. Msomi, K. Mlisana, A. von Gottberg, S. Walaza, Mushal Allam, A. Ismail, T. Mohale, A. Glass, S. Engelbrecht, G. V. Van Zyl, W. Preiser, Francesco Petruccione, A. Sigal, D. Hardie, G. Marais, N. Hsiao, S. Korsman, M. Davies, L. Tyers, I. Mudau, Denis York, C. Maslo, D. Goedhals, S. Abrahams, O. Laguda-Akingba, A. Alisoltani-Dehkordi, A. Godzik, C. K. Wibmer, B. Sewell, J. Lourenço, L. Alcântara, S. K. Kosakovsky Pond, S. Weaver, D. Martin, R. Lessells, J. Bhiman, C. Williamson, Tulio de Oliveira   +46 more
semanticscholar   +1 more source

SARS-CoV-2 and the kidney

Australian Journal of General Practice, 2021
COVID-19 has been at the forefront of public and scientific attention since the initial report in December 2019. The kidney is one of the target organs of the causative SARS-CoV-2 virus.The aim of this article is to discuss the current understanding of COVID-19 renal disease from a primary care perspective, with the caveat that our knowledge of the ...
Titus, Thomas, Rahman, Atifur
openaire   +5 more sources

The Architecture of SARS-CoV-2 Transcriptome [PDF]

Cell, 2020
SummarySARS-CoV-2 is a betacoronavirus that is responsible for the COVID-19 pandemic. The genome of SARS-CoV-2 was reported recently, but its transcriptomic architecture is unknown. Utilizing two complementary sequencing techniques, we here present a high-resolution map of the SARS-CoV-2 transcriptome and epitranscriptome. DNA nanoball sequencing shows
Kim, Dongwan, Lee, Joo-Yeon, Yang, Jeong-Sun, Kim, Jun Won, Kim, V. Narry, Chang, Hyeshik   +5 more
openaire   +5 more sources

Gastrointestinal SARS CoV-2 Infection and The Dynamic of Its Detection in Stool [PDF]

, 2020
Introduction: SARS-CoV-2 has been strongly associated with respiratory illnesses however the SARS-CoV-2 infection of the gastrointestinal tract is not fully clear.
Abbas, Mohammed, Bordon, Jose, Elbeblawy, Rafik, Gadelmoula, Islam, Kolla, Akshitha, Sinanova, Bettina   +5 more
core   +1 more source

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

FEBS Open Bio, EarlyView.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper, Sridhar Sreeramulu, Benjamin T. Lanham, Elizabeth M. Engle, David Fushman, Harald Schwalbe   +5 more
wiley   +1 more source