Results 111 to 120 of about 1,048,158 (273)

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

An In-vitro evaluation of a polyherbal formulation, against SARS-Cov-2

, 2022
Divya Kanchibhotla, Saumya Subramanian, Ravi reddy, Hari Venkatesh, Monika Pathania   +4 more
openalex   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Antigenic imprinting in SARS‐CoV‐2

Clinical and Translational Medicine, 2022
S. Momsen Reincke, Harald Prüss, Ian A. Wilson, Jakob Kreye   +3 more
doaj   +1 more source

New potential anti-SARS-CoV-2 and anti-cancer therapies of chitosan derivatives and its nanoparticles: Preparation and characterization

, 2023
Mai Ali, Mansoura I. Mohamed, Azza T. Taher, Sara H. Mahmoud, Ahmed Mostafa, Farag F. Sherbiny, Nadia G. Kandile, Hemat M. Mohamed   +7 more
openalex   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Pathogenicity of SARS‐CoV‐2 Omicron

Clinical and Translational Medicine, 2022
Hin Chu, Kwok‐Yung Yuen
doaj   +1 more source

Case-control study of activities associated with SARS-CoV-2 infection in an adult unvaccinated population and overview of societal COVID-19 epidemic counter measures in Denmark

, 2022
Pernille Kold Munch, Laura Espenhain, Christian Holm Hansen, Tyra Grove Krause, Steen Ethelberg   +4 more
openalex   +1 more source

Immunophenotypes of anti-SARS-CoV-2 responses associated with fatal COVID-19 [PDF]

, 2022
Julij Šelb, Barbara Bitežnik, Urška Bidovec Stojkovič, Boštjan Rituper, Katarina Osolnik, Peter Kopač, Petra Svetina, Kristina Cerk Porenta, Franc Šifrer, Petra Lorber, Darinka Trinkaus Leiler, Tomaž Hafner, Tina Jerič, Robert Marčun, Nika Lalek, Nina Frelih, Mojca Bizjak, Rok Lombar, Vesna Nikolić, Katja Adamič, Katja Mohorčič, Sanja Grm Zupan, Irena Šarc, Jerneja Debeljak, Ana Koren, Ajda Demšar Luzar, Matija Rijavec, Izidor Kern, Matjaž Fležar, Aleš Rozman, Peter Korošec   +30 more
openalex   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source