Results 111 to 120 of about 1,252,032 (378)

Inhibition of SARS‐CoV‐2‐mediated thromboinflammation by CLEC2.Fc

EMBO Molecular Medicine, 2023
Thromboinflammation is the major cause of morbidity and mortality in COVID‐19 patients, and post‐mortem examination demonstrates the presence of platelet‐rich thrombi and microangiopathy in visceral organs.
Pei‐Shan Sung, Cheng‐Pu Sun, Mi‐Hua Tao, Shie‐Liang Hsieh   +3 more
doaj   +1 more source

Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa

Nature, 2021
The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and third waves were driven by the Beta (B.1.351) and Delta (B.1.617.2) variants ...
R. Viana, S. Moyo, D. Amoako, H. Tegally, C. Scheepers, C. Althaus, U. J. Anyaneji, P. Bester, M. F. Boni, M. Chand, W. Choga, R. Colquhoun, M. Davids, K. Deforche, D. Doolabh, L. du Plessis, S. Engelbrecht, J. Everatt, J. Giandhari, M. Giovanetti, D. Hardie, V. Hill, N. Hsiao, A. Iranzadeh, A. Ismail, Charity Joseph, R. Joseph, Legodile Koopile, S. K. Kosakovsky Pond, M. Kraemer, Lesego Kuate-Lere, O. Laguda-Akingba, Onalethatha Lesetedi-Mafoko, R. Lessells, S. Lockman, Alexander G. Lucaci, Arisha Maharaj, Boitshoko Mahlangu, Tongai Gibson Maponga, Kamela Mahlakwane, Z. Makatini, G. Marais, D. Maruapula, K. Masupu, M. Matshaba, S. Mayaphi, N. Mbhele, Mpaphi B. Mbulawa, A. Mendes, K. Mlisana, A. Mnguni, T. Mohale, M. Moir, Kgomotso Moruisi, M. Mosepele, Gerald Motsatsi, M. Motswaledi, T. Mphoyakgosi, N. Msomi, Peter N. Mwangi, Y. Naidoo, Noxolo N. Ntuli, M. Nyaga, Lucier Olubayo, S. Pillay, Botshelo Radibe, Yajna Ramphal, U. Ramphal, J. E. San, L. Scott, R. Shapiro, L. Singh, P. Smith-Lawrence, W. Stevens, A. Strydom, K. Subramoney, N. Tebeila, D. Tshiabuila, J. Tsui, Stephanie van Wyk, S. Weaver, C. K. Wibmer, E. Wilkinson, N. Wolter, A. Zarebski, Boitumelo J. L. Zuze, D. Goedhals, W. Preiser, F. Treurnicht, M. Venter, C. Williamson, O. Pybus, J. Bhiman, A. Glass, D. Martin, A. Rambaut, S. Gaseitsiwe, A. von Gottberg, Tulio de Oliveira   +98 more
semanticscholar   +1 more source

SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation [PDF]

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a 'highly transmissible respiratory pathogen, leading to severe multi-organ damage. However, knowledge regarding SARS-CoV-2-induced cellular alterations is limited.
Jun, Sangmi, Kim, Bum-Tae, Kim, Chonsaeng, Kim, Mi-Hwa, Kim, Seong-Jun, Ku, Keun Bon, Lee, Wooseong, Moon, Hyun-Woo, Oh, Jong-Won, Shin, Hye Jin, Siddiqui, Aleem, Yi, Yoon-Sun, Yoon, Gun Young   +12 more
core   +1 more source

SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The impact of SARS‐CoV‐2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes in brain lesion activity and brain and spinal cord volumes following SARS‐CoV‐2 infection.
Tomas Uher, Dominika Stastna, Ingrid Menkyova, Vaclav Capek, Jiri Lindner, Petra Nytrova, Jan Krasensky, Eliza Varju, Miguel D'haeseleer, Eva Kubala Havrdova, Dana Horakova, Manuela Vaneckova, Niels Bergsland   +12 more
wiley   +1 more source

Whole genome sequencing of recombinant viruses obtained from co-infection and superinfection of Vero cells with modified vaccinia virus ankara vectored influenza vaccine and a naturally occurring cowpox virus

Frontiers in Immunology
Modified vaccinia virus Ankara (MVA) has been widely tested in clinical trials as recombinant vector vaccine against infectious diseases and cancers in humans and animals.
Diana Diaz-Cánova, Ugo Moens, Annika Brinkmann, Andreas Nitsche, Malachy Ifeanyi Okeke   +4 more
doaj   +1 more source

17β‐estradiol reduces SARS‐CoV‐2 infection in vitro

Physiological Reports, 2021
The COVID‐19 has originated from Wuhan, China, in December 2019 and has been affecting the public health system, society, and economy in an unheard‐of manner. There is no specific treatment or vaccine available for COVID‐19. Previous data showed that men
Robertha Mariana Rodrigues Lemes, Angelica Jardim Costa, Cynthia Silva Bartolomeo, Taysa Bervian Bassani, Michelle Sayuri Nishino, Gustavo Jose da Silva Pereira, Soraya Soubhi Smaili, Rui Monteiro de Barros Maciel, Carla Torres Braconi, Edgar Ferreira da Cruz, Ana Lopez Ramirez, Juliana Terzi Maricatto, Luiz Mario Ramos Janini, Carla Máximo Prado, Roberta Sessa Stilhano, Rodrigo Portes Ureshino   +15 more
doaj   +1 more source

On the SARS-CoV-2 Variants

Infectious Disease Reports
The evolutionary dynamics of viruses, particularly exemplified by SARS-CoV-2 during the ongoing COVID-19 pandemic, underscore the intricate interplay between genetics, host adaptation, and viral spread. This paper delves into the genetic evolution of SARS-CoV-2, emphasizing the implications of viral variants on global health.
Fabio Scarpa, Francesco Branda, Nicola Petrosillo, Massimo Ciccozzi   +3 more
openaire   +3 more sources

Effects of tuberculosis and/or HIV-1 infection on COVID-19 presentation and immune response in Africa [PDF]

, 2023
Few studies from Africa have described the clinical impact of co-infections on SARS-CoV-2 infection. Here, we investigate the presentation and outcome of SARS-CoV-2 infection in an African setting of high HIV-1 and tuberculosis prevalence by an ...
Abrahams, F, Allwood, B, Allwood, BW, Aziz, S, Bangani, N, Black, J, Blumenthal, M, Bremer, M, Burgers, W, Cerrone, M, Ciko, Z, Coussens, AK, Daroowala, R, Davis, AG, de Vries, J, du Bruyn, E, Esmail, HG, Goliath, RT, Gordon, S, Harley, YXR, Hsiao, M, Hsiao, M, Jackson, A, Lai, RPJ, Lai, RPJ, Lakay, F, Martinez-Estrada, FO, Meintjes, G, Mendelson, MS, Ntusi, N, Ntusi, NAB, Papavarnavas, T, Proust, A, Riou, C, Ruzive, S, Said-Hartley, Q, Schafer, G, Schafer, G, Serole, K, Stek, C, Tiffin, N, Wasserman, S, Whitaker, C, Wilkinson, KA, Wilkinson, KA, Wilkinson, RJ, Wilkinson, RJ, Zvinairo, K   +47 more
core  

Phenotyping Healthcare Use 2–3 Decades Before the First Multiple Sclerosis Demyelinating Event

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Phenotype hospital, physician, and emergency department (ED) visits by diagnoses and specialty up to 29 years pre‐multiple sclerosis (MS) onset versus a matched population without MS. Methods We identified people with MS (PwMS) using population‐based administrative data from Ontario, Canada (1991–2020).
Helen Tremlett, Karl Everett, Colleen J. Maxwell, Feng Zhu, Ayesha Asaf, Ping Li, Kyla A. McKay, Yinshan Zhao, Ruth Ann Marrie   +8 more
wiley   +1 more source

Animal models for SARS‐CoV‐2 infection and pathology

MedComm, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the etiology of coronavirus disease 2019 (COVID‐19) pandemic. Current variants including Alpha, Beta, Gamma, Delta, and Lambda increase the capacity of infection and transmission of SARS‐CoV‐
Zhenfei Bi, Weiqi Hong, Jingyun Yang, Shuaiyao Lu, Xiaozhong Peng   +4 more
doaj   +1 more source