Results 171 to 180 of about 98,010,213 (261)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Co‐administration of COVID‐19 and influenza vaccines has been promoted to improve coverage, but acceptance among healthcare workers (HCWs) remains uncertain. In total, 1238 participants were recruited. Participants were categorized by vaccination pattern including same‐day co‐administration, non‐concurrent vaccination, or single vaccine ...
Yu‐Yin Lin +11 more
wiley +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu +5 more
wiley +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley +1 more source
Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics
Mass Spectrometry Reviews, EarlyView.ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers +5 more
wiley +1 more source
Keeping It Native: Non‐Denaturing Approaches to Top‐Down Protein Mass Spectrometry
Mass Spectrometry Reviews, EarlyView.ABSTRACT Top‐down proteomics and top‐down mass spectrometry approaches provide direct characterization of proteoforms; the specific molecular forms of proteins, including post‐translational modifications, truncations, alternative splicing, and sequence variants.
Michael Xiao +3 more
wiley +1 more source
Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2
International audienceAntibodies play a pivotal role in protecting from SARS-CoV-2 infection, but their efficacy is challenged by the continuous emergence of viral variants.
van der Werf, Sylvie +24 more
core +1 more source
Med Research, EarlyView.This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang +4 more
wiley +1 more source
COVID‐19 Amplifies Sex‐Specific Dopamine and Glial Responses in a Parkinson's Disease Mouse Model
Movement Disorders, EarlyView.Abstract Background Exposure to environmental agents, including viral infections, may increase Parkinson's disease (PD) susceptibility, especially in males, but the neurodegenerative risk extent of COVID‐19 remains uncertain. Objectives We investigated the plausible link between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and
Ifeoluwa Awogbindin +10 more
wiley +1 more source
Waning antibodies to SARS-CoV-2 – Don't panic
The Lancet Regional Health - Europe, 2021 openaire +3 more sources
Muscle fatigue in patients with severe long COVID: A 2‐year follow‐up study
PM&R, EarlyView.Abstract Background Fatigue is recognized as one of the most persistent and debilitating symptoms of long COVID, affecting both functionality and quality of life. However, its long‐term effects, especially beyond the first year after infection, remain poorly understood.
Isabella da Silva Almeida +6 more
wiley +1 more source