Results 181 to 190 of about 99,522,423 (293)

The burden of COVID‐19 in hospitalized people with diabetes mellitus in Brazil: Insights from four years of the pandemic

Diabetic Medicine, EarlyView.
Abstract Aims Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is more severe in people with diabetes mellitus due to immune dysfunction, exacerbated inflammation and increased risk of co‐morbidities and mortality.
Taís Mendes Camargo, Bianca Aparecida Siqueira, Luiz Felipe Azevedo Marques, Lucas Silva Mello, Fernando Augusto Lima Marson   +4 more
wiley   +1 more source

T‐Cell Response After SARS‐CoV‐2 Vaccination in Patients With Hematological Malignancy

European Journal of Haematology, EarlyView.
ABSTRACT Patients with hematologic malignancies (HM) often mount poor humoral responses to SARS‐CoV‐2 vaccination due to their immunocompromised status. Protection against severe COVID‐19 is strongly related to cellular immunity, yet vaccine‐induced T‐cell responses remain incompletely characterized.
L. S. Boerenkamp, N. Scheffers, L. Brandts, G. N. Y. van Gorkom, C. R. Pothast, M. H. M. Heemskerk, L. Wieten, C. H. M. J. Van Elssen   +7 more
wiley   +1 more source

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

The FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

SARS-CoV-2 Spike Protein

This resource, provided by Anti-body Engineers, features an image of a 3D model of a SARS-CoV-2 spike protein. Users can click on the image and see a SARS-CoV-2 spike protein in iCn3D, a three-dimensional visualization platform for molecular structures ...

core   +1 more source

SARS-CoV-2 spike protein does not alter plasma fibrin clots. [PDF]

Blood Adv
Kangro K, Wolberg AS, Flick MJ.
europepmc   +1 more source

Pushing the limits of atomic force microscopy: Emerging methods for speed, resolution, and quantitative analysis

Journal of Microscopy, EarlyView.
Abstract Since its introduction 40 years ago, atomic force microscopy (AFM) has transformed nanoscale imaging across the physical and life sciences. In biology, AFM has provided unprecedented insights into nanoscale biomolecular organisation under near‐physiological conditions, revealing structures and interactions inaccessible to many conventional ...
Yueqi Wang, Daniel E. Rollins, Varun Gupta, Maya Tekchandani, Bashra A. Mahamed, George R. Heath   +5 more
wiley   +1 more source

Insights into the mechanism of action of the bipartite fusion module of SARS-CoV-2 spike protein. [PDF]

J Virol
Buga CC, Valério M, Alenquer M, Pires de Miranda M, Melo MN, Castanho MARB, Amorim MJ, Soares CM, Vicente JB, Veiga AS, Lousa D.   +10 more
europepmc   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source

Computationally Guided Design and Experimental Validation of ssDNA Aptamers Targeting the SARS-CoV-2 Spike Protein. [PDF]

Biomolecules
Márquez Montesinos JCE, Bernardez AM, Mazola Y, Vaccaro L, Sáez-Álvarez Y, Agudo R, Valdivieso E, Llorens-Berzosa S, Fenoy S, González W, Izquierdo F, Ollero D, Del Aguila C, Hurtado-Marcos C.   +13 more
europepmc   +1 more source