Results 171 to 180 of about 131,065 (253)

Combined immunization with SARS-CoV-2 spike and SARS-CoV nucleocapsid protects K18-hACE2 mice but increases lung pathology

npj Vaccines
Vaccines against SARS-CoV-2 have targeted the spike protein and have been successful at preventing disease. However, with the emergence of variants, spike-specific vaccines become less effective.
Jaekwan Kim, Alla Kachko, Prabhuanand Selvaraj, David Rotstein, Charles Brandon Stauft, Naveen Rajasagi, Yangqing Zhao, Tony Wang, Marian Major   +8 more
doaj   +1 more source

Inactivation of Pseudovirus Expressing the D614G Spike Protein Mutation using Nitric Oxide‐Plasma Activated Water

Advanced Science
Variants of concern (VOCs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) exhibit high infectivity due to mutations, particularly in the spike protein, that facilitate enhanced binding of virus to human angiotensin‐converting enzyme 2 ...
Paritosh Patel, Neha Kaushik, Tirtha Raj Acharya, Sudakshya S. Lenka, Soujanya Ghosh, Rizwan Wahab, Suresh K. Verma, Eun Ha Choi, Nagendra Kumar Kaushik   +8 more
doaj   +1 more source

Computational and Spectroscopic Insights Into the Rice Bran Derived Glu‐Gln‐Arg‐Pro‐Arg Pentapeptide as an Anticancer Agent: A DFT, Molecular Docking, and Molecular Dynamics Study

International Journal of Quantum Chemistry, Volume 126, Issue 8, April 15, 2026.
Rice bran–derived neutral EQRPR (L‐Glu‐L‐Gln‐L‐Arg‐L‐Pro‐L‐Arg) pentapeptide was structurally and biologically characterized using DFT calculations, vibrational spectroscopy, molecular docking, and molecular dynamics simulations. The DFT/wb97xd/6–31++G(d,p) level of theory showed the best agreement with the experimental spectra.
Gozde Yilmaz, Sefa Celik, Aysen E. Ozel, Sevim Akyuz   +3 more
wiley   +1 more source

2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A SAR study led to the identification of new 2‐phenylquinoline‐based derivatives that exhibit anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) activity by acting as ATP‐competitive inhibitors of nonstructural protein 13 (nsp13) helicase.
Giada Cernicchi, Maria Giulia Nizi, Roberta Emmolo, Leentje Persoons, Manon Laporte, Dirk Jochmans, Isabella Romeo, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Jacopo Spezzini, Alma Martelli, Simone Brogi, Francesca Esposito, Tommaso Felicetti, Serena Massari, Giuseppe Manfroni, Stefano Sabatini, Gianluca Sbardella, Stefano Alcaro, Johan Neyts, Angela Corona, Enzo Tramontano, Steven De Jonghe, Oriana Tabarrini   +24 more
wiley   +1 more source

Surfactant‐Enhanced Electrospun Nanofiber Filters for Efficient Viral and Bacterial Inactivation

Journal of Applied Polymer Science, Volume 143, Issue 13, April 5, 2026.
In this work, electrospun polyacrylonitrile (PAN) nanofibrous filters functionalized with surfactants (CTAB, CPC, and SDS) were developed for air filtration applications. The PAN nanofiber mats enable efficient particulate matter capture while simultaneously providing antimicrobial and antiviral activity against bacteria (E. coli and S.
Edilton N. da Silva, Paulo A. M. Chagas, Gustavo C. da Mata, Felipe A. Lima, Fabiana B. Furtado, Wanderley P. de Oliveira, Rejane M. T. Grotto, Clovis W. O. de Souza, Mônica L. Aguiar, Vádila G. Guerra   +9 more
wiley   +1 more source

Structural Constraints Acting on the SARS-CoV-2 Spike Protein Reveal Limited Space for Viral Adaptation. [PDF]

Genome Biol Evol
Herzig JC, Magwira ML, Lovell SC.
europepmc   +2 more sources

Harmonization of IgG antibody values against the SARS-CoV-2 Spike protein. [PDF]

Sci Rep
Saraiva AL, Afreixo V, Amaral P, Viana JF, Antunes I, Paiva A, Gonçalves LA, Araújo L, Machado A, Gaio V.   +9 more
europepmc   +1 more source

Thymidine phosphorylase promotes SARS-CoV-2 spike protein-driven lung tumor development. [PDF]

Front Immunol
Wallace C, Gileles-Hillel A, Cox A, Gozal D, Li W, Yue H.   +5 more
europepmc   +1 more source

SARS-CoV-2 spike protein expression drives post-acute coagulopathy. [PDF]

J Virol
Tien C-F, Lin E-J, Tsai W-H, Tsai W-T, Chen M-Y, Su Y-S, Wu H-C, Chiu Y-T, Tung W-J, Kuo Y-P, Su Y-W, Chen H-W, Chen F-J, Chuang T-H, Wang H-T, Yu G-Y.   +15 more
europepmc   +1 more source

Cellular and Molecular Mechanisms of SARS-CoV-2 Spike Protein-Induced Endothelial Dysfunction. [PDF]

Cells
Muir KC, Harris DD, Kanuparthy M, Hu J, Nho JW, Stone C, Banerjee D, Sellke FW, Feng J.   +8 more
europepmc   +1 more source