Results 151 to 160 of about 131,065 (253)

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1856-1870, June 2026.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Mast Cells in Acute COVID‐19 Patients

Allergy, EarlyView.
Ilan Zaffran, Hadas Pahima, Eli Ben‐Chetrit, Amir Jarjoui, Ilaria Puxeddu, Carl Zinner, Joana Vitte, Alexandar Tzankov, Francesca Levi‐Schaffer   +8 more
wiley   +1 more source

Advances and challenges in multiscale biomolecular simulations: artificial intelligence‐driven paradigm shift

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Molecular simulation techniques have become an invaluable tool for elucidating the fundamental principles of life at the molecular level. After nearly five decades of development, biomolecular simulations have evolved to enable the quantitative characterization of complex biomolecular events, such as protein folding, conformational dynamics ...
Wenfei Li, Wei Wang
wiley   +1 more source

Successful in vitro propagation of feline coronavirus from clinically diagnosed feline infectious peritonitis cases using Vero cells: A potential model for future research

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Feline coronavirus (FCoV) causes inapparent to progressive fatal feline infectious peritonitis (FIP) in domestic and wild cats, which affects multiple‐organ systems. Methods We investigated three clinically sick cats using different laboratory and molecular tests to diagnose and confirm FCoV and propagate the virus in Vero cell ...
Eaftekhar Ahmed Rana, Mahfuza Akther, Susan Beetson, Subir Sarker, Gabriele Rossi, Jasim M. Uddin   +5 more
wiley   +1 more source

A Next‐Generation ELISA for the Detection of Anti‐(Para)Nodal Antibodies in Autoimmune Nodopathy and COVID‐19 Vaccinated Individuals

Journal of the Peripheral Nervous System, Volume 31, Issue 2, June 2026.
ABSTRACT Background and Aims Autoimmune nodopathy (AN) is a subtype of antibody‐mediated inflammatory neuropathy targeting the node of Ranvier (NoR). Diagnosis requires detection of anti‐(para)nodal autoantibodies like contactin‐1 and neurofascin‐155 via ELISA or cell‐based assays, but protocols are inconsistent. Causes of node autoimmunity are unknown,
Luise Appeltshauser, Chiara Ruprecht, Julia Reusch, Juliane Mees, Helena Glenewinkel, Claudia Sommer, Manuel Krone, Isabell Wagenhäuser, Kathrin Doppler, Nils Petri   +9 more
wiley   +1 more source

Engagement of a Neighboring Lys Residue by a Salicylaldehyde‐Modified Glycomimetic Ligand Enables Potent and Selective Binding to DC‐SIGN Over L‐SIGN

ChemistryEurope, Volume 4, Issue 5, May 2026.
Mannose derivatives connected to the aminophilic salicylaldehyde tag show high binding affinity for C‐type lectin DC‐SIGN, favored by an imine bond with a protein's Lys residue in the ligand binding site. This reversible‐covalent binding interaction enables ligand selectivity for DC‐SIGN over the closely related L‐SIGN.
Sara Pollastri, Clara Delaunay, Giulia Antonini, Carine Froment, Michel Thépaut, Davide Pasquali, Sarah Mazzotta, Laura Belvisi, Julien Marcoux, Franck Fieschi, Alberto Dal Corso, Anna Bernardi   +11 more
wiley   +1 more source

Contemporary Applications of Chemical Libraries for Drug Discovery and Methods for Their Synthesis

ChemistryEurope, Volume 4, Issue 5, May 2026.
Screening of chemical libraries has over the past decades become a cornerstone of drug discovery. Today, a broad range of chemical libraries exist but they are often not well described in terms of diversity. This review describes current efforts which aim to visualize chemical diversity in compound collections and discuss current trends in synthetic ...
Tobias N. Hansen, Nils J. V. Hansen
wiley   +1 more source

SARS-CoV-2 spike protein interacts with and activates TLR41 [PDF]

Cell Research, 2021
Yingchi Zhao, Ming Kuang, Junhong Li, Ling Zhu, Zijing Jia, Xuefei Guo, Yaling Hu, Jun Kong, Hang Yin, Xiangxi Wang, Fuping You   +10 more
openaire   +2 more sources