Results 151 to 160 of about 99,522,423 (293)

Corrigendum: Evaluating SARS-CoV-2 Spike Protein Transfection in HEK-293T Cells for VLP Applications

Journal of Experimental Life Science
The spike protein of SARS-CoV-2 is crucial for initiating infections by binding to host cells and mediating membrane fusion. In this study, HEK-293T cells were transfected with plasmids encoding three structural proteins of SARS-CoV-2, i.e., Spike ...
Ilmiana Nurur Rohmah, Marlita Marlita, Kavana Hafil Kusuma, Yuyun Ika Christina, Dinia Rizqi Dwijayanti, Dewi Mustikaningtyas, Nashi Widodo, M. Sasmito Djati   +7 more
doaj   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Multivalent and Sequential Heterologous Spike Protein Vaccinations Effectively Induce Protective Humoral Immunity against SARS-CoV-2 Variants

Vaccines
The emergence of new SARS-CoV-2 variants continues to cause challenging problems for the effective control of COVID-19. In this study, we tested the hypothesis of whether a strategy of multivalent and sequential heterologous spike protein vaccinations ...
Rong Liu, Janhavi P. Natekar, Ki-Hye Kim, Heather Pathak, Noopur Bhatnagar, Jannatul Ruhan Raha, Bo Ryoung Park, Anchala Guglani, Chong Hyun Shin, Mukesh Kumar, Sang-Moo Kang   +10 more
doaj   +1 more source

Research Progress on V2CTx MXene‐Based Composites: Synthetic Strategies, Structure Design, and Multifunctional Applications

Carbon Energy, EarlyView.
This review systematically and comprehensively summarizes the latest research progress on V2CTx MXene. Focusing on the structural design strategies, particularly the construction of the V2CTx‐based hetero‐composite structure. Furthermore, widespread applications including electrochemical energy storage and conversion, as well as photocatalytic ...
Wenjun Zhu, Minghai Zhao, Min Fan, Jianmin Luo, Jian Tian, Xinhui Xia, Wenkui Zhang, Xinyong Tao, Yanxian Jin, Yang Xia   +9 more
wiley   +1 more source

Nanophotonic Biosensors and the Paradigm of Trans‐Scale Autonomous Bio‐Integrated Diagnostics for Addressing Health Complexities

Electron, EarlyView.
Physics‐driven advances in optical nanobiosensors for rapid, miniaturized, and point‐of‐care diagnostics for next‐generation decentralized and personalized healthcare based on sensor intelligence. ABSTRACT Public health emergencies and the escalating burden of chronic diseases necessitate a paradigm shift from centralized laboratory testing to rapid ...
Vishal Chaudhary, Harsh Sable, Sonu Sonu, Lakshita Phor, Reddicherla Umapathi, Pradeep Bhadola   +5 more
wiley   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

SARS-CoV-2 S Omicron Spike B.1.1.529

CryoEM Dataset of SARS-CoV-2 S Omicron Spike B.1.1 ...
Stahlberg, H, Myasnikov, Alexander, Trono, Didier, Lau, Kelvin, Turelli, Priscilla, Pojer, Florence, Ni, D, Beckert, Bertrand, Nazarov, Sergey   +8 more
core   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays

, 2020
International audienceSARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated viral infection are important for studying ...
Helen Y. Chu, Veesler, David, Katharine H. D. Crawford, Balazs, Alejandro, Neil P. King, David Veesler, Dingens, Adam, Bloom, Jesse, King, Neil, Alejandro B. Balazs, Eguia, Rachel, Rachel Eguia, Chu, Helen, Wolf, Caitlin, Murphy, Michael, Andrea N. Loes, Caitlin R. Wolf, Pettie, Deleah, Deleah Pettie, Keara D. Malone, Michael Murphy, Crawford, Katharine, Adam S. Dingens, Tortorici, M Alejandra, Malone, Keara, Loes, Andrea, Jesse D. Bloom, M. Alejandra Tortorici   +27 more
core   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source