Results 141 to 150 of about 99,522,423 (293)

SARS-CoV-2 infection primes cross-protective respiratory IgA in a MyD88- and MAVS-dependent manner

npj Vaccines
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is constantly evolving mutations in the Spike protein to evade humoral immunity. Respiratory tract antiviral IgA antibodies are superior to circulating IgG antibodies in preventing SARS-CoV-2 ...
Moe Kobayashi, Nene Kobayashi, Kyoka Deguchi, Seira Omori, Takeshi Ichinohe   +4 more
doaj   +1 more source

Anti-Platelet Factor 4 Antibodies Causing VITT do not Cross-React with SARS-CoV-2 Spike Protein

, 2021
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe adverse effect of ChAdOx1 nCoV-19 COVID-19 vaccine (Vaxzevria) and COVID-19 vaccine Janssen (Ad26.COV2.S), and associated with unusual thrombosis.
Scheer, Christian, Greinacher, Andreas, Hellmuth, Johannes Christian, Duerschmied, Daniel, Keppler, Oliver, Floeel, Agnes, Napp, Matthias, Wesche, Jan, Lother, Achim, Mueller, Karin Anne Lydia, Reiche, Sven, Gawaz, Meinrad, Palankar, Raghavendra, Thiele, Thomas, Muenchhoff, Maximilian, Mayerle, Julia, Vogelgesang, Antje, Hahnenkamp, Klaus, Selleng, Kathleen, Warkentin, Theodore E., Lucchese, Guglielmo, Lovreglio, Piero, Aebischer, Andrea, Stufano, Angela, Marschalek, Rolf, Rieg, Siegbert   +25 more
core   +1 more source

Ferritin as a Nanoparticle Scaffold for Plant‐Produced Next‐Generation Subunit Vaccines

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein nanoparticles offer an innovative approach to next‐generation subunit vaccine development by displaying antigenic sequences on the nanoparticle surface. Compared to traditional subunit vaccines, protein nanoparticle vaccines often show improved interaction with the immune system due to their particulate size and repetitive epitope ...
Jordan T. VanderBurgt, Richard Strasser, Christopher P. Garnham, Rima Menassa   +3 more
wiley   +1 more source

Effects of recombinant SARS-CoV-2 spike protein variants on red blood cells parameters and red blood cell distribution width

Biomedical Journal
We planned a series of experiments to investigate the possible role of spike protein of different SARS-CoV-2 variants in influencing erythrocyte biology.
Francesco Dima, Gian Luca Salvagno, Giuseppe Lippi   +2 more
doaj   +1 more source

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic1,2. Clinical manifestations of COVID-19 vary, ranging from asymptomatic infection to respiratory failure.
Florent Fauchere (16281491), Larissa Henze (5769869), Daniel Wendisch (9187136), Emre Baysal (16281494), Manuela Dingeldey (14524004), Maike Mangold (14524001), Roland Lauster (63042), Florian Kern (4461943), Philipp Georg (12059450), others (6644544), Marco Frentsch (10677069), Stefan Hippenstiel (167416), Beate Kruse (14524007), Julian Braun (12234605), Lucie Loyal (14524013), Florian Kurth (350282)   +15 more
core  

Characterization of Immune Responses to RBD‐SD1 Nanoparticle Vaccines Derived From ACE2‐Capable HKU5‐CoV‐2, NeoCoV, and HKU5 Merbecoviruses

Biotechnology and Bioengineering, EarlyView.
SpyCatcher‐mi3 nanoparticles presenting HKU5, NeoCoV, and HKU5‐CoV‐2 RBD‐SD1 induced strong, cross‐reactive IgG responses in immunized mice. The surrogate virus neutralization test demonstrated strong activity in sera from homologous vaccination. ABSTRACT Recent discoveries of merbecoviruses such as HKU5, NeoCoV, and HKU5‐CoV‐2 that use angiotensin ...
Peter J. Halfmann, Jeong Soo Lee, Augustine Duffy, Tong Wang, Bingcheng Huang, James Z. Kurdi, Ajay Inampudi, Natasha Chen, Elizabeth Frimpong, Carmen Rai, Yoshihiro Kawaoka, Ravi S. Kane   +11 more
wiley   +1 more source

SARS-CoV-2 Spike Protein Induced Signaling

, 2022
We study whether SARS-CoV-2 spike protein induces inflammatory cytokines by activating the IRF and NF-kB regulatory ...
Belinski, Lydia
core   +1 more source

SARS‐CoV‐2 infection in lung transplant recipients induces circulating exosomes with SARS‐CoV‐2 spike protein S2

Clinical and Translational Medicine, 2021
Sandhya Bansal, Sofya Tokman, Timothy Fleming, Gabriel N. Maine, Kristina Sanborn, Ramsey Hachem, Ankit Bharat, Michael A. Smith, Ross M. Bremner, T. Mohanakumar   +9 more
doaj   +1 more source

Microfiltration (MF) and Ultrafiltration (UF) for Sewage and Surface Water Concentration for SARS‐CoV‐2 and Other Enveloped Viruses' Detection in Wastewater‐Based Epidemiology (WBE)

Biotechnology and Bioengineering, EarlyView.
ABSTRACT This study objective was to evaluate hollow fiber membranes for concentration of enveloped enteric viruses in sewage and surface water samples. Microfiltration (MF, 0.2 µm nominal pore size) and ultrafiltration (UF, 100 kDa molecular weight cut‐off) hollow fiber membranes were compared for the concentration of the bovine respiratory syncytial ...
Rodrigo Almeria Ragio, Rodrigo de Freitas Bueno, Roseli Frederigi Benassi, Eduardo Lucas Subtil   +3 more
wiley   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source