Results 121 to 130 of about 99,522,423 (293)
SARS-CoV‑2 Variants Are Selecting for Spike Protein Mutations That Increase Protein Stability
, 2021 The emergence of variants of SARS-CoV-2 with mutations in their spike protein are a major cause for concern for the efficacy of vaccines and control of the pandemic.
David Shorthouse (2733004) +1 more
core +2 more sources
Advanced Science, EarlyView.An ATP‐driven molecular switch, comprising viral nucleocapsid (N) protein and host helicase DDX21, dynamically modulates SARS‐CoV‐2 RNA G‐quadruplex (G4) heterogeneity. These viral G4s feature non‐canonical ion‐dependence and act as energy‐sensitive structural checkpoints.
Ya‐Ting Zheng +8 more
wiley +1 more source
SARS-CoV-2 spike protein retains binding to cells expressing LRRC15 when presented as trimers.
, 2023 Representative flow cytometry traces depicting recombinant spike protein binding to HEK293 cells transfected to express the indicated receptors (left) are shown next to the quantified percentages of cells that bound spike.
Edward J. D. Greenwood (14564377) +15 more
core +1 more source
Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli
Advanced Science, EarlyView.Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma +18 more
wiley +1 more source
Determinants of susceptibility to SARS-CoV-2 infection in murine ACE2
Journal of VirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme 2 (ACE2) as a receptor to enter host cells, and primary receptor recognition of the spike protein is a major determinant of the host range of SARS-CoV-2 ...
Takashi Kondo +10 more
doaj +1 more source
Prozone effect in anti-SARS-CoV-2 spike protein immunoassay testing, August 2022.
Prozone effect in anti-SARS-CoV-2 spike protein immunoassay testing, August 2022.
Stephen J. Pont (18271974) +6 more
core +1 more source
Advanced Science, EarlyView.Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha +5 more
wiley +1 more source
Inhibition of Rab1B Impairs Trafficking and Maturation of SARS-CoV-2 Spike Protein
, 2023 Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) utilizes cellular trafficking pathways to process its structural proteins and move them to the site of assembly.
Cornelius Rohde +4 more
core +1 more source
Advanced Science, EarlyView.Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie +24 more
wiley +1 more source
Advanced Science, EarlyView.FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun +13 more
wiley +1 more source