ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu +2 more
wiley +1 more source
Targeting PTP4A3 with KVX-053 mitigates alcohol-amplified SARS-CoV-2 spike protein-induced acute lung injury. [PDF]
Solopov PA +4 more
europepmc +1 more source
An Investigations‐Based Undergraduate Computational Chemistry Course
Chemistry 164 is a hands‐on undergraduate computational chemistry course at Pomona College using publicly available materials (https://tinyurl.com/PomonaChem164) and structured around literature‐based investigations of organic structure and reactivity, isotope effects, NMR parameters, and organometallic systems.
Daniel J. O'Leary
wiley +1 more source
The conserved QTQTX motif in the SARS-CoV-2 spike protein is dispensable for cleavage and lung cell entry of the emerging variant BA.3.2. [PDF]
Zhang L +8 more
europepmc +1 more source
In this study, a mouse monoclonal and rabbit polyclonal antibodies were used as capture and detection antibodies, respectively, to develop a DAS‐ELISA that can be used for viral antigen detection. ABSTRACT Objectives Double‐antibody sandwich enzyme‐linked immunosorbent assay (DAS‐ELISA) is a simple and accurate method for detecting viral pathogens ...
Bo Dong +7 more
wiley +1 more source
Intravitreal exposure to the SARS-CoV-2 spike protein is associated with aggravated retinal lesions in a murine model of central retinal vein occlusion. [PDF]
Liu S +6 more
europepmc +1 more source
Genetic Engineering Efforts to Generate Chlamydomonas Strains for Large‐Scale Biomolecule Production
This represents the main aspects relevant to potential industrialization of Chlamydomonas. ABSTRACT Chlamydomonas reinhardtii is an established model microalga. Its easy manipulation, metabolic flexibility and tractable genomes allowed researchers to investigate fundamental processes such as photosynthesis using genetic studies for decades ...
Sofia Inturri +2 more
wiley +1 more source
Oral yeast-displayed SARS-CoV-2 spike protein vaccine enhanced by trimerization and flagellin peptide. [PDF]
Saveii T +4 more
europepmc +1 more source
ABSTRACT Aim This pilot study explored signs of immunological cross‐reactivity between SARS‐CoV‐2 and human coronaviruses (HCoVs) in a Swedish school setting. Methods A cross‐sectional, hypothesis‐generating study was conducted late 2020 before vaccines against COVID‐19 were available.
Lina Schollin Ask +14 more
wiley +1 more source
Harmonization of IgG antibody values against the SARS-CoV-2 Spike protein. [PDF]
Saraiva AL +9 more
europepmc +1 more source

