Results 221 to 230 of about 99,522,423 (293)

Exploring the Development of Vaccine Platforms, With a Particular Focus on the COVID‐19 Pandemic

Acta Paediatrica, Volume 115, Issue 11, Page 2421-2426, November 2026.
ABSTRACT Vaccines have been a cornerstone of human health for more than 200 years and one of the most important tools to reduce childhood deaths caused by pathogens. The concept of vaccines is basically to take something safe, make it immunogenic and induce an immune response in the host that will protect it against something dangerous. Live attenuated
Matti Sällberg
wiley   +1 more source

Thymidine phosphorylase promotes SARS-CoV-2 spike protein-driven lung tumor development. [PDF]

Front Immunol
Wallace C, Gileles-Hillel A, Cox A, Gozal D, Li W, Yue H.   +5 more
europepmc   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, Volume 36, Issue 6, November 2026.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

SARS-CoV-2 spike protein expression drives post-acute coagulopathy. [PDF]

J Virol
Tien C-F, Lin E-J, Tsai W-H, Tsai W-T, Chen M-Y, Su Y-S, Wu H-C, Chiu Y-T, Tung W-J, Kuo Y-P, Su Y-W, Chen H-W, Chen F-J, Chuang T-H, Wang H-T, Yu G-Y.   +15 more
europepmc   +1 more source

Knocking Out Two Polyphenol Oxidase Genes Significantly Improves Recombinant Protein Purification in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 11, Page 5588-5596, November 2026.
ABSTRACT Efficient purification remains a key technical challenge affecting the recovery efficiency of recombinant proteins in plant‐based systems. Complex metabolites, particularly polyphenols, often cause recombinant protein aggregation during purification.
Hai‐Ping Diao, Hui‐Xin Meng, Xue‐Jiao Xu, Zeng‐Lin Zhang, Jian‐Feng Zhang, Yong‐Feng Guo, Inhwan Hwang, Shi‐Jian Song   +7 more
wiley   +1 more source

Cellular and Molecular Mechanisms of SARS-CoV-2 Spike Protein-Induced Endothelial Dysfunction. [PDF]

Cells
Muir KC, Harris DD, Kanuparthy M, Hu J, Nho JW, Stone C, Banerjee D, Sellke FW, Feng J.   +8 more
europepmc   +1 more source

Plant‐Based Production of Human Major Histocompatibility Complex Class II Molecules

Plant Biotechnology Journal, Volume 24, Issue 11, Page 5616-5630, November 2026.
ABSTRACT Major histocompatibility complex class II (MHC II) protein triggers adaptive immune responses by presenting antigens on antigen‐presenting cells (APCs) to be recognised by CD4+ T cells. Recombinant MHC II proteins are effective for the analysis of peptide‐binding interaction, detection of antigen‐specific T‐cells and clinical testing for donor‐
Abdelaziz Ramadan, Hiroko Miyadera, Kaho Oka, Kohei Ishikawa, Toshiya Kobayashi, Misaki Kobayashi, Mitsunori Shiroishi, Emiko Noguchi, Kenji Miura   +8 more
wiley   +1 more source

In-Depth Molecular Dynamics Simulations Reveal Ligand-Induced Modulations of the HSPA8-SARS-CoV-2 Spike Protein Interaction. [PDF]

Int J Mol Sci
Navhaya LT, Monama MZ, Matsebatlela TM, Makhoba XH.   +3 more
europepmc   +1 more source

Bacteriophage P22 Virus‐Like Particles as Nanoscale Protein Scaffolds for Plant Synthetic Biology

Plant Biotechnology Journal, Volume 24, Issue 11, Page 5671-5683, November 2026.
ABSTRACT Advancing the utility of plant synthetic biology requires the continued development of protein engineering tools. Self‐assembling protein compartments, such as virus‐like particles (VLPs), provide versatile scaffolds for synthetic biology. However, few plant‐expressed VLPs have demonstrated broad amenability to protein engineering, restricting
Maxim D. Harding, Mark A. Jackson, Edward K. Gilding, David J. Craik, Frank Sainsbury, Nicole Lawrence   +5 more
wiley   +1 more source

SARS-CoV-2 Spike Protein Amyloid Fibrils Impair Fibrin Formation and Fibrinolysis. [PDF]

Biochemistry
Westman H, Hammarström P, Nyström S.
europepmc   +1 more source