Results 131 to 140 of about 679,279 (310)

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

SARS-CoV-2 seropositivity by participant demographics and SARS-CoV-2 exposures and risk behaviors.

SARS-CoV-2 seropositivity by participant demographics and SARS-CoV-2 exposures and risk behaviors.
Sombo Fwoloshi (4321150), Kalubi Kalenga (18297785), Elizabeth Heilmann (18297776), Tannia Tembo (6785636), Mpanji Siwingwa (3690319), Izukanji Sikazwe (531945), Bupe Kabamba (18297779), Felix Chilambe (18297782), Lloyd B. Mulenga (6785501), Ruchi Yadav (189335), Samuel Yingst (30536), Victoria Seffren (18297788), Theodora Savory (5340821), Simon Agolory (847088), Muzala Kapina (18275558), Carolyn Bolton-Moore (428685), Andrew F. Auld (8967719), John Simwanza (18297791), Julie R. Gutman (5108699), Chabu Kangale (15271594), Conceptor Mulube (8309931), Jonas Z. Hines (16520538), Eric Rogier (3433718)   +22 more
core   +1 more source

Reporte N°19: Vigilancia de variantes de SARS-CoV-2 en la CABA, provincias de Buenos Aires, Santa Fe, Córdoba y Neuquén. Actualización al 12/04/2021 [PDF]

, 2021
Participantes en este reporte: Nodo secuenciación HNRG: Mercedes Nabaes; Laura Valinotto; Stephanie Goya; Mónica Natale; Silvina Lusso, Sofía Alexay; Dolores Acuña; Mariana Viegas.
Gobierno de la Provincia de Córdoba. Ministerio de Salud. Laboratorio Central, Consorcio Argentino de Genómica de SARS-CoV-2, Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología Dr. José María Vanella   +2 more
core  

SARS-CoV-2 genomes of French mink nested within the 20A clade, together with SARS-CoV-2 from human sampled at the same period of time.

, 2023
SARS-CoV-2 genomes of French mink nested within the 20A clade, together with SARS-CoV-2 from human sampled at the same period of time.
Sandrine Corbet (16884127), Véronique Beven (4621126), Sylvie Van der Werf (3467405), Etienne Simon-Lorière (4856482), Vincent Enouf (175900), Evelyne Picard-Meyer (331154), Céline Richomme (475107), Marine Wasniewski (4491511), Meriadeg Le Gouil (16884130), Estelle Leperchois (16884121), Yannick Blanchard (577101), Bryce Leterrier (16884124), Flora Donati (10319260), Elodie Monchatre-Leroy (6862502), Franck Boué (4600645)   +14 more
core   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

SARS-CoV-2 sequence distribution.

, 2022
SARS-CoV-2 sequence distribution.
Marilena V. Iorio (12096129), Elda Tagliabue (222687), Andrea Cairo (11576801), Silvia Spena (393632), Flora Peyvandi (397638)   +4 more
core   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

SARs-Cov-2 spike protein and ACE2

, 2022
Model built as part of a collaborative molecular simulation SARS-COv-2 project investigating the interactions between the SARS-CoV-2 spike protein and ACE2 protein, each component being embedded in its lipid bilayer.
Laurent Chaloin (12269174), Serge Perez (12091370), Bernard Maigret (12269172)   +2 more
core   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

SARS-CoV-2 protein composition.

, 2021
SARS-CoV-2 protein composition.
Jeroen A. A. Demmers (11681950), Mart M. Lamers (9998247), Peter C. Wever (11681941), Bart L. Haagmans (7849811), Karel Bezstarosti (463432), Wouter A. S. Doff (11681938), Khoa T. D. Thai (11681944), Jeroen J. A. van Kampen (11681947)   +7 more
core   +1 more source