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Reporte N°26: Vigilancia activa de variantes de SARS-CoV-2. Análisis genómico de casos de variante Delta en la provincia de Córdoba y en la CABA. Actualización al 10/08/2021 [PDF]

, 2021
Participantes en este reporte: Nodo de secuenciación y análisis de variantes del HNRG (CABA): Sofía Alexay; Dolores Acuña; Mercedes Nabaes; Guillermo Thomas; Laura Valinotto; Stephanie Goya; Mónica Natale; Silvina Lusso; Mariana Viegas; Alicia S ...
Gobierno de la Provincia de Córdoba. Ministerio de Salud. Laboratorio Central, Consorcio Argentino de Genómica de SARS-CoV-2, Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología Dr. José María Vanella   +2 more
core   +1 more source

SARS-CoV-2 testing.

, 2021
SARS-CoV-2 testing.
Mattias Mandorfer (584776), Lukas Hartl (51870), Michael Trauner (124235), Tobias Meischl (6751562), Thomas Reiberger (143056), Bernhard Scheiner (829816), Christian Müller (65008), Katharina Pomej (11337336), Matthias Pinter (4330267), Lorenz Balcar (11337339)   +9 more
core   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Epidemiology, transmission dynamics and control of SARS: the 2002-2003 epidemic [PDF]

, 2004
This paper reviews current understanding of the epidemiology, transmission dynamics and control of the aetiological agent of severe acute respiratory syndrome (SARS).
Hedley, A, Leung, Gabriel M, Ghani, Azra C, Christophe Fraser, Lam, T, Anderson, RM, Ghani, AC, Lam, TH, Azra C. Ghani, Donnelly, C, Leung, GM, Fraser, C, Ferguson, Neil M, Fraser, Christophe, Donnelly, CA, Hedley, AJ, Christl A. Donnelly, Anderson, Roy M, Ferguson, NM, Riley, Steven, Roy M. Anderson, Leung, G, Hedley, Anthony J, Anthony J. Hedley, Ghani, A, Ferguson, N, Anderson, R, Donnelly, Christl A, Steven Riley, Riley, S, Neil M. Ferguson, Gabriel M. Leung, Tai H. Lam   +32 more
core   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Nucleotide analogues as inhibitors of SARS‐CoV Polymerase

Pharmacology Research & Perspectives, 2020
SARS‐CoV‐2, a member of the coronavirus family, has caused a global public health emergency. Based on our analysis of hepatitis C virus and coronavirus replication, and the molecular structures and activities of viral inhibitors, we previously reasoned ...
Jingyue Ju, Xiaoxu Li, Shiv Kumar, Steffen Jockusch, Minchen Chien, Chuanjuan Tao, Irina Morozova, Sergey Kalachikov, Robert N. Kirchdoerfer, James J. Russo   +9 more
doaj   +1 more source

REGEN‐COV antibody combination in patients with lymphoproliferative malignancies and SARS‐CoV‐2 infection

eJHaem, 2022
Patients with lymphoproliferative diseases are at high risk for SARS‐CoV‐2‐related complications and mortality. The role of casirivimab and imdevimab (REGEN‐COV), a neutralizing antibody cocktail, to treat immunocompromised hemato‐oncological patients ...
Yotam Bronstein, Irit Avivi, Yael C Cohen, Eugene Feigin, Chava Perry, Yair Herishanu   +5 more
doaj   +1 more source

Evaluation of EPISEQ SARS-CoV-2 and a Fully Integrated Application to Identify SARS-CoV-2 Variants from Several Next-Generation Sequencing Approaches

, 2022
Whole-genome sequencing has become an essential tool for real-time genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide.
Ligeon, Véronique, Emmanuelle Santiago, Vignola, Alexandre, Véronique Ligeon, Josset, Laurence, Regue, Hadrien, Abel Betraoui, Magali Jaillard, Griffon, Aurélien, Brengel-Pesce, Karen, Destras, Gregory, Tournoud, Maud, Nathalie Mugnier, Bal, Antonin, Maud Tournoud, Alexandre Vignola, Laurence Josset, Aurélien Griffon, Bruno Simon, Santiago, Emmanuelle, Gregory Destras, Jaillard, Magali, Karen Brengel-Pesce, Simon, Bruno, Antonin Bal, Mugnier, Nathalie, Maxence Rambaud, Cheynet, Valérie, Hadrien Regue, Valérie Cheynet, Betraoui, Abel, Rambaud, Maxence   +31 more
core   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source