This study developed 3D‐printable THA‐Col microgels for delivering BMP‐7 cmRNA. The key result is that hMSCs transfected on the biomaterials showed BMP‐7 secretion levels comparable to pre‐transfected hMSCs, therefore introducing a cmRNA‐activated matrix to promote bone healing.
Daphne van der Heide+7 more
wiley +1 more source
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
J. Lan+10 more
semanticscholar +1 more source
PCM-SAR: Physics-Driven Contrastive Mutual Learning for SAR Classification [PDF]
Existing SAR image classification methods based on Contrastive Learning often rely on sample generation strategies designed for optical images, failing to capture the distinct semantic and physical characteristics of SAR data. To address this, we propose Physics-Driven Contrastive Mutual Learning for SAR Classification (PCM-SAR), which incorporates ...
arxiv
Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho+3 more
wiley +1 more source
Options for combination therapy of influenza and ARVI with combined drugs
According to the World Health Organization (WHO), 3 to 5 million cases of influenza are registered every year worldwide, of which 250--500 thousand are fatal.
T. V. Sologub+2 more
doaj +1 more source
An RBC membrane camouflaged, cell‐penetrating peptides R8‐based drug delivery system is constructed to achieve a synergistic combination of natural compounds triptolide (TP) and celastrol (Cel), inducing tumor cell apoptosis, reducing tumor metastasis invasion and triggering autophagy disorder in breast cancer and liver cancer.
Qian Cheng+6 more
wiley +1 more source
O występowaniu Corophium curvispinum G. O. Sars f. devium Wundsch i Carinogammarus roeselii (Gervais) w dorzeczu Noteci = Ueber das Vorkommen von Corophium curvispinum G. O. Sars f. devium Wundsch sowie Carinogammarus roeselii (Gervais) im Gebiet des Noteć-Flusses [PDF]
Włodzimierz Julian Kulmatycki
openalex +1 more source
Recommendations for coronavirus infection in rheumatic diseases treated with biologic therapy. [PDF]
The Coronavirus-associated disease, that was first identified in 2019 in China (CoViD-19), is a pandemic caused by a bat-derived beta-coronavirus, named SARS-CoV2.
Ansari, Aftab A+6 more
core
Surface modification using mussel‐derived polydopamine (PDA) is a versatile and robust biocompatible strategy that enables direct application to various epidermal surfaces, regardless of their morphological complexity or surface characteristics. The PDA‐coated epidermis exhibits multiple anti‐biofouling functionalities, including antibacterial and anti‐
Su Eon Lee+14 more
wiley +1 more source
Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In Vivo mRNA Delivery
Lipid nanoparticles (LNPs) have rapidly become the delivery system of choice for RNA therapeutics. Here, a rational design approach is taken to improve the effectiveness of LNPs based on an ionizable thioether lipid library. The incorporation of unsaturated tails and bulkier, hydrophobic head groups significantly enhances their functionality and ...
Eleni Samaridou+4 more
wiley +1 more source