Results 11 to 20 of about 1,671,123 (378)
, 2009 Five years after the first severe acute respiratory syndrome (SARS) outbreak, several candidate SARS-coronavirus (CoV) vaccines are at various stages of preclinical and clinical development. Based on the observation that SARSCoV infection is efficiently controlled upon passive transfer of antibodies directed against the spike (S) protein of SARS-CoV ...
Albert D. M. E. Osterhaus +1 more
openaire +3 more sources
Journal of Hospital Infection, 2004 Since its emergence in the first months of 2003, the epidemic of severe acute respiratory syndrome (SARS) has been characterized by rapid spread among healthcare workers (HCWs). Uncertainty about the route of transmission of the virus suggests the use of respirators that can protect HCWs against both droplet nuclei and droplet transmission, rather than
Puro Vincenzo +2 more
openaire +3 more sources
Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1
New England Journal of Medicine, 2020 Aerosol and Surface Stability of SARS-CoV-2 In this research letter, investigators report on the stability of SARS-CoV-2 and SARS-CoV-1 under experimental conditions.
N. van Doremalen +12 more
semanticscholar +1 more source
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
New England Journal of Medicine, 2020 Background Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle–encapsulated mRNA-based vaccine that encodes the prefusion ...
L. Baden +36 more
semanticscholar +1 more source
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
Science, 2020 How SARS-CoV-2 binds to human cells Scientists are racing to learn the secrets of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), which is the cause of the pandemic disease COVID-19. The first step in viral entry is the binding of the viral
R. Yan +5 more
semanticscholar +1 more source
The proximal origin of SARS-CoV-2
Nature Network Boston, 2020 SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-
K. Andersen +5 more
semanticscholar +1 more source
Detection of SARS-CoV-2 in Different Types of Clinical Specimens.
Journal of the American Medical Association (JAMA), 2020 This study describes results of PCR and viral RNA testing for SARS-CoV-2 in bronchoalveolar fluid, sputum, feces, blood, and urine specimens from patients with COVID-19 infection in China to identify possible means of non-respiratory transmission.
Wenling Wang +6 more
semanticscholar +1 more source
Characteristics of SARS-CoV-2 and COVID-19
Nature Reviews Microbiology, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which ...
Ben Hu, Hua Guo, P. Zhou, Zhènglì Shí
semanticscholar +1 more source
Nature Microbiology, 2020 The present outbreak of a coronavirus-associated acute respiratory disease called coronavirus disease 19 (COVID-19) is the third documented spillover of an animal coronavirus to humans in only two decades that has resulted in a major epidemic.
Alexander E. Susan C. Ralph S. Raoul J. Christian Anastasia Gorbalenya Baker Baric de Groot Drosten Gulyaeva H +17 more
semanticscholar +1 more source
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection
Science, 2021 Variable memory Immune memory against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) helps to determine protection against reinfection, disease risk, and vaccine efficacy.
J. Dan +20 more
semanticscholar +1 more source