Results 201 to 210 of about 520,560 (251)

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Exploring potential phytocompounds from black cumin as drug molecules against SARS-CoV-2 infections through bioinformatics analysis. [PDF]

PLoS One
Ali MA, Sheikh H, Reza MS, Paul TR, Noor T, Kumar N, Bhat MA, Mollah MNH.   +7 more
europepmc   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Gut microbiota alterations and microbial translocation in HIV/SARS-CoV-2 co-infected patients. [PDF]

Front Cell Infect Microbiol
Yan X, Zhang X, Wang L, Song W, Qi T, Wang Z, Tang Y, Sun J, Xu S, Yang J, Shao Y, Chen Y, Wang J, Chen J, Zhang R, Liu L, Shen Y.   +16 more
europepmc   +1 more source

A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection

Advanced Science, EarlyView.
A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Marcia Domínguez, David Azorín‐Soriano, Araceli Lérida‐Viso, Jessie García‐Fleitas, Paula M Soriano‐Teruel, Jennifer Soler Beatty, Paula Rodrigo‐Martínez, Pau Arroyo, Sara Rojas‐Vázquez, Isabel Fariñas, Félix Sancenón, Juan F. Blandez, Alba García‐Fernández, Ramón Martínez‐Máñez   +13 more
wiley   +1 more source

Significant Production of Serum and Mucosal Anti-Spike-IgA Antibodies After Vaccine-Encoded or SARS-CoV-2-Infection-Induced Spike-Exposures in Patients with Asthma Treated with Monoclonal Antibodies Compared to Conventional Therapy. [PDF]

J Asthma Allergy
Almanzar G, Broderdörp A, Mees J, Frey M, Herth FJF, Schneider MA, Trinkmann F, Prelog M.   +7 more
europepmc   +1 more source

Nanoyeast-based impedimetric biosensor with mutated single chain antigen-binding fragment anchoring for SARS-CoV-2 detection. [PDF]

Biomed Microdevices
Hensel RC, Materón EM, Macedo AJG, Raimundo BVB, Kadowaki MAS, Fuentes DLP, Tavares Junior AG, de Aquino Penteado L, Zanelli CF, de Azevedo RB, Chorilli M, de Medeiros AI, Carrilho E, Oliveira ON, Valentini SR, Souza-Moreira TM.   +15 more
europepmc   +1 more source

Bovine coronavirus and SARS-CoV-2 seroprevalence in livestock: marked host-species differences and insights from the first large-scale neutralization survey. [PDF]

Sci Rep
Fusco G, Picazio G, de Martinis C, Cardillo L, Brandi S, Martucciello A, Barca L, Riccelli E, Fiorito F, Pucciarelli A, Decaro N.   +10 more
europepmc   +1 more source

Computational Optimization of CRISPR-Cas13a sgRNAs Targeting the SARS-CoV-2 Spike Gene for SHERLOCK-Based Diagnostics. [PDF]

Evol Bioinform Online
Ahmadzadeh M, Akbarian F, Sanati MH, Motaharirad H, Farrokhi F.   +4 more
europepmc   +1 more source