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Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet+10 more
core +1 more source
While severe acute respiratory syndrome (SARS) is increasing in prevalence throughout the world, there had not been a documented case of SARS in pregnancy until early 2003, when a pregnant woman infected with SARS sought care at this New Jersey Hospital in March 2003.
Johanna Gorab+7 more
openaire +3 more sources
A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology
The ongoing pandemic spread of a new human coronavirus, SARS-CoV-2, which is associated with severe pneumonia/disease (COVID-19), has resulted in the generation of tens of thousands of virus genome sequences.
A. Rambaut+7 more
semanticscholar +1 more source
Mechanisms of SARS-CoV-2 entry into cells
The unprecedented public health and economic impact of the COVID-19 pandemic caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been met with an equally unprecedented scientific response.
C. B. Jackson+3 more
semanticscholar +1 more source
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet+10 more
core +1 more source
Neurologic Features in Severe SARS-CoV-2 Infection
Neurologic Features in SARS-CoV-2 Infection In a consecutive series of 64 patients with Covid-19 and ARDS, 58 of whom underwent neurologic examination, severe agitation and corticospinal signs were...
Julie Helms+11 more
semanticscholar +1 more source
Meirion R. Evans BA(Hons), MB, BCh, FRCP, FFPHM Clinical Senior Lecturer Department of Epidemiology, Statistics & Public Health University of Wales College of Medicine Honorary Regional Epidemiologist PHLS Communicable Disease Surveillance Centre (Wales) Abton House, Wedal Road, Cardiff CF14 3QX United Kingdom Temporary Advisor on SARS, World Health ...
Anil T. Ahuja+2 more
openaire +5 more sources
Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos
The active site of the essential CDK1 kinase is generated by core structural elements, among which the PSTAIRE motif in the critical αC-helix, is universally conserved in the single CDK1 ortholog of all metazoans.
Xiaofei Ma+5 more
doaj +1 more source
Background The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) first broke out in Wuhan (China) and subsequently spread worldwide. Chloroquine has been sporadically used in treating SARS-CoV-2 infection.
Xueting Yao+14 more
semanticscholar +1 more source
Cell entry mechanisms of SARS-CoV-2
Significance A key to curbing SARS-CoV-2 is to understand how it enters cells. SARS-CoV-2 and SARS-CoV both use human ACE2 as entry receptor and human proteases as entry activators.
J. Shang+6 more
semanticscholar +1 more source