Results 161 to 170 of about 331,841 (258)

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, EarlyView.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

Velociraptor Machine Learning Quantifies Similarity to Known Cell Types and Matches Cells Across Flow and Imaging Cytometry Platforms

Cytometry Part A, EarlyView.
ABSTRACT Suspension flow cytometry enables high‐throughput cellular profiling at the single cell level, but these data lack positional information. Conversely, tissue‐based imaging cytometry techniques reveal a cell's location within the tissue architecture and can provide insight into cell biology.
Claire E. Cross, Asa A. Brockman, Rebecca A. Ihrie, Jonathan M. Irish   +3 more
wiley   +1 more source

Respiratory pandemic risk in the Anthropocene: A One Health framework and GISRS+ agenda. [PDF]

One Health
Lee JM, Kim HO, Kim YJ, Singh MK, Kim SS, Yeo SG.   +5 more
europepmc   +1 more source

From patterns to predictions: a framework for the spatial epidemiology of wildlife diseases

Ecography, EarlyView.
Wildlife diseases pose a significant threat to biodiversity conservation, public health, and livestock. Spatial epidemiology provides a robust framework to understand disease dynamics and guide policy and management. However, the rapid proliferation of spatial methods has largely occurred in isolation across disciplines, leaving the field without a ...
Cesar Herraiz, Pelayo Acevedo
wiley   +1 more source

Wastewater Respiratory Virus Surveillance in Remote Community, Alaska, USA, 2022-2024. [PDF]

Emerg Infect Dis
Lefferts B, Leary A, Bruden D, Blake I, Richman C, Sixberry S, Vicente M, Pak J, Hodges E, Keck JW.   +9 more
europepmc   +1 more source

SARS-CoV-2 3CLpro inhibits the replication of influenza viruses through the cleavage of NP and PA. [PDF]

Virol Sin
Du L, Cai X, Peng Z, Wang M, Li H, Liu X, Zhang Z, Cao M, Zhang S, He Z, Zhang Z, Yan Y, Lin Q, Xue Y, Guo D, Pan JA, Chen YQ, Peng X.   +17 more
europepmc   +1 more source

Nanophotonic Biosensors and the Paradigm of Trans‐Scale Autonomous Bio‐Integrated Diagnostics for Addressing Health Complexities

Electron, EarlyView.
Physics‐driven advances in optical nanobiosensors for rapid, miniaturized, and point‐of‐care diagnostics for next‐generation decentralized and personalized healthcare based on sensor intelligence. ABSTRACT Public health emergencies and the escalating burden of chronic diseases necessitate a paradigm shift from centralized laboratory testing to rapid ...
Vishal Chaudhary, Harsh Sable, Sonu Sonu, Lakshita Phor, Reddicherla Umapathi, Pradeep Bhadola   +5 more
wiley   +1 more source

SARS-CoV-2 infection induces functional impairment of vitamin D receptor signaling to drive interleukin 6-dependent hyperinflammation in mononuclear phagocytes. [PDF]

PLoS One
Valdés-López JF, di Filippo D, Penagos S, Hernández-Sarmiento LJ, Arroyave-Ospina JC, Rojas M, Urcuqui-Inchima S, Aguilar-Jiménez W, Navas MC.   +8 more
europepmc   +1 more source

Nanoscopy reveals heparan sulfate clusters as docking sites for SARS-CoV-2 attachment and entry. [PDF]

Elife
Han S, Wang X, Li T, Mohseni A, Kosik I, Chan CY, López-Muñoz AD, Matthias J, Suddaby R, Wang Z, Jin AJ, Wurm CA, Yewdell JW, Wu LG.   +13 more
europepmc   +1 more source

Revolutionizing Healthcare With Paper‐Based Nucleic Acid Testing

Exploration, EarlyView.
This work summarizes strategies to enhance paper‐based devices for nucleic acid testing. Key approaches include optimizing paper platforms, improving nucleic acid amplification, and refining labeling/signaling methods. These advancements aim to boost sensitivity, speed, and usability, making paper‐based diagnostics more effective for point‐of‐care ...
Hong Zhang, Yi Yang, Heng Li, Xiaolin Hu, Hui Xiao, Dou Wang, Sergio Benardini, Wei Gu, Yang Luo   +8 more
wiley   +1 more source