Results 171 to 180 of about 331,841 (258)

Targeting eEF1A1 With Baicalein to Block eEF1A1/Prdx4 Interaction for Treating Sepsis‐Mediated Lung Injury

Exploration, EarlyView.
Targeting eEF1A1 with baicalein disrupts the eEF1A1‐Prdx4 interaction to prevent RNF14‐mediated ubiquitination and degradation of Prdx4. This stabilizes Prdx4 to suppress NF‐κB, thereby alleviating sepsis‐induced acute lung injury. ABSTRACT Sepsis is a systemic inflammatory response syndrome triggered by an uncontrolled host response to infection ...
Jing Chang, Hui‐Lin Zhang, Qi‐Meng Zhu, Si‐Wen Hui, Xin‐Rong Xu, Mahmood Brobbey Oppong, Yan‐Li Feng, Juan Zhang, Cheng‐Peng Sun, Feng Qiu   +9 more
wiley   +1 more source

Heterogeneity of Airborne Virus Transmission in the Built Environment: A Narrative Review. [PDF]

Pathog Immun
Zhang Y, Krupinsky KC, Lauring AS, Marr LC.   +3 more
europepmc   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Early HHV-6 IgG and IgA responses during acute SARS-CoV-2 infection in relation to long COVID: a multicohort observational study. [PDF]

EBioMedicine
Choudhury A, Burry MJ, Kwon WJ, Yin X, Rallistan A, Presti S, Ndakwah GS, Cheng EQ, Kalaycioglu M, Harris M, Frankovich J, Karlson EW, Bollyky J, Utz PJ, Prestwood TR.   +14 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Divergent lipid utilization strategies of SARS-CoV-2 and MERS-CoV revealed by comparative multi-omics profiling of infected mouse lung tissues. [PDF]

Front Immunol
Jang Y, Kim H, Li Y, Lee JS, Lee J, Lee HW, Cho NH, Cho JY.   +7 more
europepmc   +1 more source

The Preparation of Novel Fluorenes Inspired by Hipposudoric Acid

Helvetica Chimica Acta, EarlyView.
In this research we report on the design and synthesis of a series of fluorene‐based derivatives loosely inspired by the tricyclic framework of hipposudoric acid. Preparation of sixteen novel N‐alkylated derivatives was accomplished via a series of concise one‐step amide N‐alkylation reactions.
Munib Uddin, Freya Harrison, Florida Koçi, Stephen P. Wren   +3 more
wiley   +1 more source

A late-stage multi-dimensional intervention rescues lethal viral pneumonia in an aged hamster model. [PDF]

Mol Biomed
Zhou M, Liu X, Miao J, Lin Y, Xiao H, Wu K, Zhang L, Li X, Yang X, Chen L, Ma J, Wang W, Xu N, Li J, Zhu H, Guan Y, Xia N, Cheng T, Yuan L.   +18 more
europepmc   +1 more source