Results 171 to 180 of about 2,592,842 (396)

An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus. [PDF]

, 2005
A new SARS animal model was established by inoculating SARS coronavirus (SARS-CoV) into rhesus macaques (Macaca mulatta) through the nasal cavity. Pathological pulmonary changes were successively detected on days 5-60 after virus inoculation.
Chen, Liangbiao, Cong, Zhe, Duan, Shumin, Gao, Hong, Guo, Lan, Guo, Li, He, Wei, Hong, Tao, Huang, Lan, Jiang, Hong, Liu, Depei, Liu, Peimao, Liu, Qian, Liu, Yali, Marasco, Wayne A, Qin, Chuan, Qu, Jianguo, Ren, Lili, Ruan, Li, She, Mingpeng, Sun, Yili, Tong, Wei, Tu, Xinming, Wang, Jianwei, Wang, Yanbin, Wei, Qiang, Yang, Renquan, Zhang, Hua, Zhang, Huiyuan, Zhang, Jianmin, Zhu, Hua   +30 more
core  

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Cell, 2020
Bette T. Korber, W. Fischer, S. Gnanakaran, Hyejin Yoon, J. Theiler, W. Abfalterer, N. Hengartner, E. Giorgi, Tanmoy Bhattacharya, B. Foley, K. Hastie, M. Parker, D. Partridge, C. Evans, T. Freeman, T. D. de Silva, C. McDanal, L. Perez, Haili Tang, Alex Moon-Walker, S. Whelan, C. Labranche, E. Saphire, D. Montefiori, A. Angyal, Rebecca Brown, Laura Carrilero, Luke R. Green, Danielle C. Groves, Katie Johnson, A. Keeley, B. Lindsey, P. Parsons, M. Raza, S. Rowland-Jones, Nikki Smith, Rachel M. Tucker, Dennis Wang, M. Wyles   +38 more
semanticscholar   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Sars-Cov-2 Virus and Eye

Open Access Journal of Ophthalmology, 2022
It is a minireview about the impact of SARS COVID-19 pandemia on Ophthalmology. Since 1990’s this virus was studied and some researchers showed its retinotropism. Nowadays, according to the World Health Organization guidelines, we explain how Italian ophthalmologist and nurses faced the effect of this pandemia on our daily work.
openaire   +1 more source

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

PLoS ONE, 2012
Background Severe acute respiratory syndrome (SARS) emerged in China in 2002 and spread to other countries before brought under control. Because of a concern for reemergence or a deliberate release of the SARS coronavirus, vaccine development was ...
C. Tseng, E. Sbrana, N. Iwata-Yoshikawa, Patrick C. Newman, Tania M Garron, R. Atmar, C. Peters, R. Couch   +7 more
semanticscholar   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source

Antibody Response to COVID-19 mRNA Vaccine in Patients With Lung Cancer After Primary Immunization and Booster: Reactivity to the SARS-CoV-2 WT Virus and Omicron Variant

, 2022
Rajesh M. Valanparambil, Jennifer W. Carlisle, Susanne L. Linderman, Akil Akthar, Ralph Linwood Millett, Lilin Lai, Andrés Chang, Ashley A. McCook‐Veal, Jeffrey M. Switchenko, Tahseen H. Nasti, Manpreet Saini, Andreas Wieland, Kelly E. Manning, Madison Ellis, Kathryn M. Moore, Stephanie L. Foster, Katharine Floyd, Meredith E. Davis-Gardner, Venkata Viswanadh Edara, Mit Patel, Conor Steur, Ajay K. Nooka, Felicia M. Green, Margaret A. Johns, Fiona O’Brein, Uma Shanmugasundaram, Veronika I. Zarnitsyna, Hasan Ahmed, Lindsay E. Nyhoff, Grace Mantus, Garett Michael, Srilatha Edupuganti, Madhusmita Behra, Rustom Antia, Jens Wrammert, Mehul S. Suthar, Madhav V. Dhodapkar, Suresh S. Ramalingam, Rafi Ahmed   +38 more
openalex   +2 more sources

CRISPR in MOF Formulation with Enhanced Stability, Activity, and Altered PAM Specificity for Broad‐Spectrum Diagnosis of Bacterial Sepsis

Advanced Science, EarlyView.
CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal, Zilong Liu, Meera G. Nair, Juhong Chen   +3 more
wiley   +1 more source

Reverse genetics of SARS-related coronavirus using vaccinia virus-based recombination.

PLoS ONE, 2012
Severe acute respiratory syndrome (SARS) is a zoonotic disease caused by SARS-related coronavirus (SARS-CoV) that emerged in 2002 to become a global health concern.
Sjoerd H E van den Worm, Klara Kristin Eriksson, Jessika C Zevenhoven, Friedemann Weber, Roland Züst, Thomas Kuri, Ronald Dijkman, Guohui Chang, Stuart G Siddell, Eric J Snijder, Volker Thiel, Andrew D Davidson   +11 more
doaj   +1 more source