Results 11 to 20 of about 2,592,842 (396)

Molecular Architecture of the SARS-CoV-2 Virus [PDF]

Cell, 2020
SUMMARYSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus responsible for the COVID-19 pandemic. Despite recent advances in the structural elucidation of SARS-CoV-2 proteins and the complexes of the spike (S) proteins with the cellular receptor ACE2 or neutralizing antibodies, detailed architecture of the intact virus ...
Hangping Yao, Yutong Song, Yong Chen, Nanping Wu, Jialu Xu, Chujie Sun, Jiaxing Zhang, Tianhao Weng, Zheyuan Zhang, Zhigang Wu, Linfang Cheng, Danrong Shi, Xiangyun Lu, Jianlin Lei, Max Crispin, Yigong Shi, Lanjuan Li, Sai Li   +17 more
openaire   +6 more sources

A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2–spike protein–protein interaction [PDF]

Nature Biotechnology, 2020
Chee Wah Tan, Wan Ni Chia, Xijian Qin, Pei Liu, Mark Chen, Charles Kevin Tiu, Zhiliang Hu, Vivian Chih-Wei Chen, Barnaby Edward Young, Wan Rong Sia, Yee‐Joo Tan, Randy Foo, Yongxiang Yi, David Chien Lye, Danielle E. Anderson, Lin‐Fa Wang   +15 more
openalex   +2 more sources

Aetiology: Koch's postulates fulfilled for SARS virus. [PDF]

Nature, 2003
Severe acute respiratory syndrome (SARS) has recently emerged as a new human disease, resulting globally in 435 deaths from 6,234 probable cases (as of 3 May 2003). Here we provide proof from experimental infection of cynomolgus macaques (Macaca fascicularis) that the newly discovered SARS-associated coronavirus (SCV) is the aetiological agent of this ...
Fouchier, RAM, van Doornum, GJJ, van den Hoogen, BG, Peiris, M, Lim, W, Osterhaus, ADME, Schutten, M, van Amerongen, G, Kuiken, T, Stohr, K   +9 more
semanticscholar   +7 more sources

The reproductive number of the Delta variant of SARS-CoV-2 is far higher compared to the ancestral SARS-CoV-2 virus

Journal of Travel Medicine, 2021
The Delta variant is now replacing all other SARS-CoV-2 variants. We found a mean R0 of 5.08, which is much higher than the R0 of the ancestral strain of 2.79. Rapidly ramping up vaccine coverage rates while enhancing public health and social measures is
Y. Liu, J. Rocklöv
semanticscholar   +1 more source

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Nature, 2022
The recent emergence of B.1.1.529, the Omicron variant1,2, has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of ...
P. Halfmann, S. Iida, K. Iwatsuki-Horimoto, Tadashi Maemura, Maki Kiso, S. Scheaffer, T. Darling, Astha Joshi, S. Loeber, Gagandeep Singh, S. Foster, Baoling Ying, J. Case, Zhenlu Chong, Bradley M. Whitener, Juan I. Moliva, K. Floyd, M. Ujie, N. Nakajima, Mutsumi Ito, R. Wright, Ryuta Uraki, Prajakta Warang, M. Gagne, Rong Li, Yuko Sakai-Tagawa, Yanan Liu, Deanna P Larson, J. Osorio, J. Hernandez-Ortiz, Amy R. Henry, K. Ciuoderis, K. Florek, M. Patel, Abby E. Odle, L. Wong, A. Bateman, Zhongde Wang, V. Edara, John Franks, T. Jeevan, Thomas P. Fabrizio, J. Debeauchamp, L. Kercher, P. Seiler, A. Gonzalez-Reiche, E. Sordillo, Lauren A. Chang, H. van Bakel, V. Simon, B. H. A. A. S. R. C. M. K. A. Z. M. I. A. E. J. A. L. Alburquerque Alshammary Amoako Aslam Banu Cognigni, B. Alburquerque, H. Alshammary, A. Amoako, S. Aslam, R. Banu, C. Cognigni, M. Espinoza-Moraga, K. Farrugia, A. van de Guchte, Z. Khalil, M. Laporte, I. Mena, A. Paniz‐Mondolfi, J. Polanco, A. Rooker, L. Sominsky, D. Douek, N. Sullivan, Larissa B. Thackray, H. Ueki, S. Yamayoshi, M. Imai, S. Perlman, R. Webby, R. Seder, M. Suthar, A. García-Sastre, M. Schotsaert, Tadaki Suzuki, A. Boon, M. Diamond, Y. Kawaoka   +82 more
semanticscholar   +1 more source

Structure of SARS-CoV-2 membrane protein essential for virus assembly

Nature Communications, 2022
The coronavirus membrane protein (M) is the most abundant viral structural protein and plays a central role in virus assembly and morphogenesis. However, the process of M protein-driven virus assembly are largely unknown.
Zhikuan Zhang, N. Nomura, Y. Muramoto, Toru Ekimoto, Tomoko Uemura, Kehong Liu, Moeko Yui, N. Kono, J. Aoki, M. Ikeguchi, Takeshi Noda, S. Iwata, U. Ohto, Toshiyuki Shimizu   +13 more
semanticscholar   +1 more source

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Nature Communications, 2020
Since 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks, SARS-CoV in 2002–2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late 2019. However, little is currently known about the biology of SARS-CoV-2.
Xiuyuan Ou, Yan Liu, X. Lei, Pei Li, Dan Mi, L. Ren, Li Guo, Ruixuan Guo, Ting Chen, Jiaxin Hu, Zichun Xiang, Z. Mu, Xing Chen, Jieyong Chen, Keping Hu, Q. Jin, Jianwei Wang, Zhaohui Qian   +17 more
semanticscholar   +1 more source

Recommendations for a safety dental care management during SARS-CoV-2 pandemic

Revista Panamericana de Salud Pública, 2020
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted mainly through droplets, sneezes and aerosols, there is a high risk of transmission during dental procedures.
Paulo Ricardo Martins-Filho, Vanessa Tavares de Gois-Santos, Carolina Santos Souza Tavares, Elisama Gomes Magalhães de Melo, Edmundo Marques do Nascimento-Júnior, Victor Santana Santos   +5 more
doaj   +1 more source

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

New England Journal of Medicine, 2020
Aerosol and Surface Stability of SARS-CoV-2 In this research letter, investigators report on the stability of SARS-CoV-2 and SARS-CoV-1 under experimental conditions.
N. van Doremalen, T. Bushmaker, Dylan H. Morris, M. Holbrook, Amandine Gamble, Brandi N. Williamson, A. Tamin, J. Harcourt, N. Thornburg, S. Gerber, J. Lloyd-Smith, E. de Wit, V. Munster   +12 more
semanticscholar   +1 more source

Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract

Nature Reviews Microbiology, 2021
Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract infections that produce a wide spectrum of clinical disease severity in humans.
T. Flerlage, David F. Boyd, Victoria A. Meliopoulos, P. Thomas, S. Schultz‐Cherry   +4 more
semanticscholar   +1 more source