Results 141 to 150 of about 54,638 (265)

4‐Octyl Itaconate Attenuates Age‐Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
4‐Octyl itaconate (4‐OI) attenuates age‐induced parotid gland dysfunction through the suppression of fibrosis and lipid deposition by AMPKα/PPARα and the inhibition of oxidative stress via the AMPKα/Nrf2 signaling pathway. 4‐OI activates AMPKα, which in turn stimulates both the PPARα and Nrf2 pathways. Activation of PPARα enhances FAO and reduces lipid
Yun Chen, Tianyuan Gong, Zhongyan Shan, Jing Lai, Yiming Xu, Han Zhao, Lilei Zhu   +6 more
wiley   +1 more source

Network Pharmacology and In Vivo Evaluation of Modified Huanglian Wendan Decoction in Polycystic Ovary Syndrome With Insulin Resistance: Association With AGE–RAGE‐Related Signaling

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
An integrated network pharmacology, chemical profiling, molecular docking, molecular dynamics, and in vivo strategy shows that Modified Huanglian Wendan Decoction improves reproductive and metabolic abnormalities in a rat model of PCOS with insulin resistance.
Xi Chen, Xing Yang, Xinni Wang, Dan Chou, Chenghong Zheng   +4 more
wiley   +1 more source

"Gestire il mare”. La questione delle risorse marine in ambito interdisciplinare

, 2013
Sasa, Raicevich, Sasa Raicevich, Bulian, Giovanni   +2 more
core   +1 more source

Exploring the Neuropharmacological Potential of Ligustrum sinense Relevant to Parkinson's Disease: In Vivo and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Ligustrum sinense (L. sinense) leaf extract exhibited moderate antioxidant activity (DPPH IC50 = 73.56 ± 2.18 µg/mL) and was evaluated for neuropharmacological effects at 200 and 400 mg/kg using elevated plus maze, open‐field, hole‐cross, and hole‐board tests.
Sowmitro Das, S. M. Istiaque Hamim, Md Nazmul Hasan Zilani, Kazi Sneha Chhando, Puza Das, Md Ridoy Hossain, Md. Imtiaz, Jebin Tasmin, Roney Miah, Md. Nazmul Hasan   +9 more
wiley   +1 more source

Computational strategies to address therapeutic resistance in estrogen receptor‐positive breast cancer: A narrative review of molecular docking, molecular dynamics simulations, and emerging therapeutic targets

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Computational drug discovery integrates molecular docking, molecular dynamics simulations, and translational clinical targeting to identify next‐generation therapeutics that overcome endocrine resistance in ER‐positive breast cancer. Combined with multi‐omics, artificial intelligence, and biomarker‐guided precision oncology, these approaches accelerate
Emmanuel Ifeanyi Obeagu, Yaregal Asres
wiley   +1 more source

Introduzione

, 2013
Sasa Raicevich, Sasa, Raicevich, Giovanni Bulian, Bulian, Giovanni   +3 more
core   +1 more source

Design of a Laccase Bioelectrode Using Multipoint Covalent Immobilization: Behavior Under Different Stress Conditions and Long‐Term Storage

Electroanalysis, Volume 38, Issue 10, October 2026.
Multipoint covalent immobilization of laccase on a modified carbon paper electrode. Robust biointerface with operational stability under chemical, thermal, mechanical, electrical, and storage stress conditions. The practical implementation of enzyme bioelectrodes is limited by the inherent lability of proteins, which require mild conditions to maintain
W. I. García‐García, G. A. Huerta‐Miranda, K. Juárez, M. Miranda‐Hernández   +3 more
wiley   +1 more source

Local electrostatics governs tryptophan oxidation and enables rational stability engineering in antibodies. [PDF]

MAbs
Lenka S, Mehta S, Stephens N, Seeger F, Liang WC, Watkins A, Zarzar J, Jafari N, Puno R, Azumaya C, Kelly R, Wu S, Chiu C, Hazen M, Wu Y, Irudayanathan FJ, Alavattam S, Kelley R, Izadi S.   +18 more
europepmc   +1 more source

Extracellular Vesicle‐Bound Bacterial Toxin Pneumolysin Triggers Membrane Engagement and Damage Beyond Canonical Pore Formation

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Bacterial toxin hijacks host microvesicles to breach cell membranes Microvesicles derived from challenged host cells carrying the pneumococcal pore‐forming toxin pneumolysin promote fusion with target cells and membrane permeabilisation. Our integrated experimental and computational study reveals a mechanism by which PLY‐lipid interactions enable ...
Aswathy C. Sagilkumar, Avinashi Lal Kushwaha, Anushka Shitut, Dheeraj Kumar Sarkar, Sruthika Sukumar, Subhajit Mahanty, Somnath Dutta, Jagannath Mondal, Karthik Subramanian   +8 more
wiley   +1 more source

Protein language model-generated enzyme sequences exhibit high stability in molecular dynamics simulations. [PDF]

Front Artif Intell
Fassi EMA, Nicolini M, Saitto E, Valentini G, Casiraghi E, Grazioso G.   +5 more
europepmc   +1 more source