Results 151 to 160 of about 54,638 (265)

EvoMut: A computational framework for engineering oxidative stability in proteins

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Amino acid oxidation is a major cause of protein instability and loss of function in therapeutic and industrial settings. Although methionine, cysteine, tryptophan, tyrosine, histidine, lysine, and arginine residues are widely recognized as oxidation‐prone, only a subset of such residues is dominant functional hotspots, and not all are ...
Seyed Shahriar Arab, Chenlin Hsieh, Nathan E. Lewis   +2 more
wiley   +1 more source

Guide to SASA

Guide to Serbian academy of sciences and ...
openaire   +1 more source

LC-MS/MS Quantification and Solvent-Exposure Modeling Reveal a Mismatch Between Linker Exposure and Payload Release in Wild-Type Trastuzumab-VC-PABC-MMAE in Rat Plasma. [PDF]

Biomed Chromatogr
Takahashi K, Yamazaki S, Matsuda Y.
europepmc   +1 more source

Conformational ensembles of the disordered 4E‐BP2:eIF4E complex restrained by smFRET experiments

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Eukaryotic cap‐dependent translation initiation is regulated by binding of the predominantly folded eukaryotic initiation factor 4E (eIF4E) to the intrinsically disordered eIF4E binding proteins (4E‐BPs). Here, we report full‐length atomistic conformational ensembles generated by IDPConformerGenerator and optimized by X‐EISDv2 workflow for ...
Spencer Smyth, Zi Hao Liu, Thomas E. Tsangaris, Teresa Head‐Gordon, Julie D. Forman‐Kay, Claudiu C. Gradinaru   +5 more
wiley   +1 more source

The alarmone pGpp inhibits translation through GTP depletion. [PDF]

Nucleic Acids Res
England KA, Trinquier A, McKinney LK, Wang JD, Feaga HA.   +4 more
europepmc   +1 more source

SASA-CLIP: Structure-Aware Alignment with a Gaussian Prior for Fine-Grained Video Action Recognition. [PDF]

Sensors (Basel)
Han X, Si W, Zhang H, Yang M, Ma L, Feng Y.   +5 more
europepmc   +1 more source

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1717-1737, October 2026.
ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman, Claudio Pedrick, Cara A. Kreck, Ricardo L. Mancera   +3 more
wiley   +1 more source

Integrative Single‐Cell Transcriptomics, Multi‐Omics Analyses, and Computational Pharmacology Reveal Macrophage Heterogeneity and the Putative THBS1‐CD36 Axis in Coronary Atherosclerosis

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
Single‐cell and multi‐omics analyses identified THBS1+ macrophages as a terminally differentiated, hypoxia‐adaptive population driving coronary atherosclerosis through THBS1‐CD36 signaling with lymphatic endothelial cells. Targeting CD36 with SMS121 and leveraging a THBS1+ macrophage gene signature enabled therapeutic prediction and accurate risk ...
Jianpeng Li, Xinrui Liu, Run Shi, Lin Yang, Rong Gu   +4 more
wiley   +1 more source

Psychometric Properties of the Greek Version of the ASKAT: Assessing Teachers' Knowledge and Attitudes Toward ADHD. [PDF]

F1000Res
Boukouvala P, Soulis SG, Kotsis K, Siafaka V.   +3 more
europepmc   +1 more source

Extending the Glass Chain:Exhibition, SASA Gallery, Adelaide

, 2018
Exhibition Dates: November 2018Venue: The South Australian School of Art (SASA) Gallery, Adelaide, AustraliaThe Gläserne Kette (‘Glass’ or ‘Crystal’ Chain, depending on the translation) is also referred to as the utopian correspondence.
Keay, Cath; id_orcid
core