Results 161 to 170 of about 54,638 (265)

Unveiling the Diagnostic Value and Potential Therapeutic Targets of Phenylalanine Metabolism in Pancreatic Cancer via Integrated Multi‐Omics and Machine Learning

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
MR identified phenylalanine as a causal PC risk factor (OR 1.18). A 5‐gene RF model (AUC 0.955) highlighted SLC6A14 as the top biomarker. Single‐cell analysis revealed epithelial–immune crosstalk. Molecular docking identified genistein (−9.1 kcal/mol) as a lead SLC6A14‐targeting compound.
Xing Liu, Yibin Li, Fangfang Qin, Jianghong Ou   +3 more
wiley   +1 more source

Beyond the Active Site: First‐In‐Class Leishmania Infantum Trypanothione Reductase Dimerization Disruptors as Antileishmanial Leads

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
This review outlines a pioneering strategy to inhibit Leishmania infantum trypanothione reductase by disrupting its dimer interface. From peptides to small‐molecule proteomimetics, multiple chemotypes achieved potent enzymatic inhibition and notable cellular antileishmanial activity, highlighting a new therapeutic paradigm.
María‐José Camarasa, Miguel Maldonado, Alvaro de la Cruz‐Potenciano, Sonia de Castro   +3 more
wiley   +1 more source

Integrating network toxicology and transcriptomics to identify CXCL8, EGFR, PTPRC, MYC, and AKT1 as key targets of microplastic-induced miscarriage. [PDF]

Medicine (Baltimore)
Niu L, Zhang X, Chen Y, Song G, Li J, Xia Y.   +5 more
europepmc   +1 more source

Sodium Channel Blockers Demonstrate Binding Affinity for the Tandem Tudor Domain of the Epigenetic Hub UHRF1

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
An investigation of the tandem Tudor domain (TTD) domain of UHRF1 identified and extensively characterized the local anesthetic hydroxyprocaine as a strong ligand capable of activating related genes such as p53 and also highlighted a new, potentially druggable intramolecular interaction between TTD and UBL.
Efstratios Tsakalidis, Mariangela Giannouli, Ifigeneia Akrani, Anthi Panara, Eleni Katalagarianou, Kyriaki Degaita, Maria Giahou, Konstantina Kyriakou, Maria Routsi, Panagiota Efstathia Nikolaou, Evangelia Tsitsou, Aggeliki Tsoka, Constantinos C. Vorgias, Emmanuel Mikros, Evangelos Gikas, Eleni K. Efthimiadou, Vassilios Myrianthopoulos   +16 more
wiley   +1 more source

Molecular Dynamics Simulation and MM/PBSA Analysis of α-Mangostin Stabilization in Soluplus^® and Kollidon^® VA64-Based Amorphous Solid Dispersions. [PDF]

Int J Mol Sci
Firmansyah F, Budiman A, Muchtaridi M, Fakih TM, Mohammed AFA, Mahmoud SA, Elamin KM, Wathoni N.   +7 more
europepmc   +1 more source

Amphipathic β‑Sheet-Forming Octapeptide Self-Assembly Using the Martini Potential Family. [PDF]

ACS Omega
Maity D, Qiao B.
europepmc   +1 more source

Correction: Association between the incidence of infusion-related reactions by obinutuzumab and the dose of corticosteroid as premedication: a multicenter retrospective cohort study. [PDF]

J Pharm Health Care Sci
Ohtsubo T, Yamamoto K, Matumoto S, Ito K, Sasa Y, Tomishima K, Dote S, Makihara K, Wakasugi Y, Mitsuie T, Yamagiwa K, Sato K, Hasegawa H, Uoshima N, Kitahiro Y, Tomogane K.   +15 more
europepmc   +1 more source

SASA Congress Abstracts

Southern African Journal of Anaesthesia and Analgesia, 2023
openaire   +1 more source

SASA QCD arXiv

The SASA-QCD arXiv submission file is the .tex source that walks into the front door of the global physics community. Standard LaTeX article class, amsmath, hyperref, geometry, TikZ inline figure — everything arXiv requires to compile cleanly with no external dependencies.
openaire   +2 more sources

Multi-Site Aggregation of p53: Insights from Self- and Co-Aggregation of Multiple Aggregation-Prone Regions. [PDF]

ACS Omega
He J, Sun H, Gong Z, Wu X, Hong L, Guo T, Lei J.   +6 more
europepmc   +1 more source