Results 51 to 60 of about 955,972 (287)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Survey on Adaptive Multi-Channel MAC Protocols in VANETs Using Markov Models

IEEE Access, 2018
A medium access control (MAC) protocol is designed to disseminate safety messages reliably and rapidly to improve the safety and efficiency of vehicles on the road in vehicular ad-hoc networks (VANETs).
Vandung Nguyen, Oanh Tran Thi Kim, Chuan Pham, Thant Zin Oo, Nguyen H. Tran, Choong Seon Hong, Eui-Nam Huh   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Exact D-optimal designs of experiments for linear multiple regression with heteroscedastic observations

Журнал Белорусского государственного университета: Математика, информатика, 2018
In article the problem of construction of exact D-optimal designs of experiments for linear multiple regression in a case when variance of errors of observations depend on a point in which is made is investigated. The class functions describing change of
Valery P. Kirlitsa
doaj  

Keeping Up with Phosphorus Dynamics: Overdue Conceptual Changes in Vegetative Filter Strip Research and Management

Frontiers in Environmental Science, 2022
Vegetative filter strips (VFS) are best management practices with the primary aim of protecting surface waters from eutrophication resulting from excess nutrient inputs from agricultural sources.
David Ramler, David Ramler, Marc Stutter, Marc Stutter, Gabriele Weigelhofer, Gabriele Weigelhofer, John N. Quinton, Rebecca Hood-Nowotny, Peter Strauss   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

DIFFERENT ROLES AND DESIGNS OF HETERO-GATE DIELECTRIC IN SINGLE- AND DOUBLE-GATE TUNNEL FIELD-EFFECT TRANSISTORS

Tạp chí Khoa học Đại học Đà Lạt, 2020
Hetero-gate dielectric (HGD) engineering not only suppresses the ambipolar current but also enhances the on-current of tunnel field-effect transistors (TFETs).
Nguyễn Đăng Chiến, Lưu Thế Vinh, Huỳnh Thị Hồng Thắm, Chun Hsing Shih   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Magnetless Optical Circulator Based on an Iron Garnet with Reduced Magnetization Saturation

Molecules, 2021
A three-port circulator for optical communication systems comprising a photonic crystal slab made of a magneto-optical material in which an magnetizing element is not required to keep its magnetic domains aligned is suggested for the first time.
Gianni Portela, Miguel Levy, Hugo E. Hernandez-Figueroa   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source