Results 61 to 70 of about 955,972 (287)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Alabama road map and directory, Tempo Designs, Chicago, Illinois 1975-76

, 1975
The digitization of this collection was funded by a gift from EBSCO ...
Tempo Designs
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Synthesis of Sliding Mode Control Strategy for T-Type Grid Inverter in Presence Grid Voltage Disturbance

Energies
The paper proposes a new hybrid sliding mode control algorithm based on saturated-type reaching law for current regulation of a grid-following inverter in a microgrid connected to the power grid, ensuring system stability under severe main grid voltage ...
Albert Sawiński, Piotr Chudzik, Karol Tatar   +2 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Two factor saturated designs: cycles, Gini index and state polytopes [PDF]

, 2014
In this paper we analyze and characterize the saturated fractions of two-factor designs under the simple effect model. Using Li et al.ear algebra, we define a criterion to check whether a given fraction is saturated or not.
ROGANTIN M. P., Fontana R., Rogantin, M.P., ROGANTIN, MARIA PIERA, Fontana, Roberto, Rapallo F., RAPALLO, Fabio, Rapallo, F., FONTANA R   +8 more
core   +1 more source

Cut saturation for p-cycle design [PDF]

2006 IEEE Region 5 Conference, 2006
Preconfigured protection cycles (p-cycles) provide recovery times for mesh networks that are near the recovery times of BLSR ring networks while providing lower spare-to-working capacity ratios. However, the efficiency of p-cycles defined by the spare-to-working capacity ratio is affected by the topology of the network.
Khalid Al-Snaie, Dale R. Thompson
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Integrating the Grading Entropy Theory (GET) into a Physics-Informed Neural Network (PINN) to predict soil hydraulic properties

Results in Engineering
The soil's hydraulic properties are fundamental for most geotechnical analyses and designs. For fully saturated soils, the Soil Saturated Hydraulic Conductivity (SSHC) is employed to quantify the capacity of the soil to transport liquid water.
Rodrigo Polo-Mendoza, David Mašín, Jose Duque   +2 more
doaj   +1 more source