Results 61 to 70 of about 2,043,285 (313)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The Energy Dependence of the Saturation Momentum from RG Improved BFKL Evolution [PDF]

, 2002
We study the energy dependence of the saturation momentum in the context of the collinearly improved Leading and Next to Leading BFKL evolution, and in the presence of saturation boundaries.
Altarelli, Armesto, Balitsky, Balitsky, Balitsky, Balitsky, Camici, Camici, Ciafaloni, Ciafaloni, Ciafaloni, Ciafaloni, D.N. Triantafyllopoulos, Dokshitzer, Fadin, Ferreiro, Golec-Biernat, Golec-Biernat, Golec-Biernat, Golec-Biernat, Gotsman, Gribov, Gribov, Iancu, Iancu, Iancu, Iancu, Jalilian-Marian, Jalilian-Marian, Jalilian-Marian, Kharzeev, Kovchegov, Kovchegov, Kovchegov, Kovchegov, Kuraev, Levin, Lipatov, McLerran, McLerran, McLerran, Mueller, Mueller, Mueller, Mueller, Ross, Salam, Salam, Weigert   +48 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Saturation Mutagenesis of the Transmembrane Region of HokC in Escherichia coli Reveals Its High Tolerance to Mutations [PDF]

, 2021
María Teresa Lara Ortiz, V Garcia, Gabriel del Rio   +2 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Deuterium retention in recrystallized tungsten exposed to high-flux plasma with fluences up to 1 × 1029 m−2

Nuclear Fusion
Plasma fluence at the divertor of a future magnetic confinement fusion device can accumulate up to ∼10 ^28 –10 ^29 m ^−2 per year. Yet hydrogen isotope (HI) retention under such high-fluence plasma exposure has been rarely reported.
Yi-Wen Sun, Hao Yin, Han-Feng Song, Jun Wang, Han-Qing Wang, Long Cheng, Yue Yuan, Hai-Shan Zhou, Thomas Schwarz-Selinger, T. W. Morgan, Guang-Hong Lu   +10 more
doaj   +1 more source

Holographic Pomeron: Saturation and DIS

, 2012
We briefly review the approach to dipole-dipole scattering in holographic QCD developed in ARXIV:1202.0831. The Pomeron is modeled by exchanging closed strings between the dipoles and yields Regge behavior for the elastic amplitude.
Alexander Stoffers, E. A. Kuraev, Ismail Zahed, P. Tribedy, V. N. Gribov, Ya. Ya. Balitsky   +5 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Adaptive control circuit prevents amplifier saturation [PDF]

, 1968
Adaptive control circuit prevents saturation of push-pull output amplifiers used in low-power, low-torque suspension system. The adaptive control circuit senses how near the output amplifiers are to saturation and sets the B voltage in such a way as to ...
Nondsieck, A. J.
core   +1 more source

Saturation of the Turbulent Dynamo

, 2015
The origin of strong magnetic fields in the Universe can be explained by amplifying weak seed fields via turbulent motions on small spatial scales and subsequently transporting the magnetic energy to larger scales.
Bovino, Stefano, Federrath, Christoph, Klessen, Ralf S., Schleicher, Dominik R. G., Schober, Jennifer   +4 more
core   +1 more source