Results 71 to 80 of about 2,043,285 (313)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Macro-micro mechanical behavior research on gas hydrate bearing coal based on parallel bonding model

Meitan xuebao
Discrete element simulation of triaxial compression test was carried out to study the effects of confining pressure and saturation on the macro and meso mechanical properties of gas hydrate bearing coal (GHBC).
Nannan WANG, Xia GAO, Jizhe ZHANG, Baoyong ZHANG, Qiang WU   +4 more
doaj   +1 more source

Robust ${L_{2}} - {L_{\infty}}$ Filter Design for Uncertain 2-D Continuous Nonlinear Delayed Systems With Saturation

IEEE Access, 2018
This paper discusses the L2 - L∞ filter design problem for non-linear two-dimensional (2-D) uncertain continuous systems with state delays and saturation.
Zhaoxia Duan, Imran Ghous, Jahanzeb Akhtar, Khurram Ali, Mujtaba Hussain Jeffery   +4 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Improving the visualization and detection of tissue folds in whole slide images through color enhancement

Journal of Pathology Informatics, 2010
Objective : The objective of this paper is to improve the visualization and detection of tissue folds, which are prominent among tissue slides, from the pre-scan image of a whole slide image by introducing a color enhancement method that enables the ...
Pinky A Bautista, Yukako Yagi
doaj   +1 more source

Saturation of interband absorption in graphene

, 2010
The transient response of an intrinsic graphene, which is caused by the ultrafast interband transitions, is studied theoretically for the range of pumping correspondent to the saturated absorption regime.
D. Potter, F. T. Vasko, F. T. Vasko
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Precise Reflectance/Transmittance Measurements of Highly Reflective Optics with Saturated Cavity Ring-Down Signals

Photonics
In this paper, a data processing approach was developed to accurately extract the ring-down time and amplitude of the saturated cavity ring-down (CRD) signal; both were utilized to determine simultaneously the high reflectance and residual transmittance ...
Yanling Han, Bincheng Li, Jing Wang, Hao Cui, Tianming Wang   +4 more
doaj   +1 more source

Assessment of the colors of the melanin pigment in acral compound nevus by using a novel dermoscopy technique with surgical light illumination and saturation analysis

Dermatology Practical & Conceptual, 2019
Introduction On dermoscopy, the amount and location of melanin pigment can be assessed on the basis of its colors, ranging from black, brown to blue-gray.
Hiroshi Sakai, Kyoko Tonomura, Hirotsugu Shirabe, Masaru Tanaka   +3 more
doaj   +1 more source