Results 41 to 50 of about 3,364,057 (201)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ingeniería e Investigación, 2010 Este artículo está basado en el planteamiento metodológico desarrollado en el Manual de Capacidad de Carreteras de Estados Unidos (HCM - Highway Capacity Manual), de la Transportation Research Board (TRB), para el análisis de capacidad y niveles de ...
Ricardo José Peña Lindarte
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Analysis of preferential flow migration in unsaturated transparent soil
Rock and Soil Mechanics, 2022 In order to realize the visualization of unsaturated preferential flow migration of soil, a column device was designed to carry out unsaturated seepage tests.
QUE Yun +3 more
doaj +1 more source
Turbulent structures, integral length scale and turbulent kinetic energy (TKE) dissipation rate in compound channel flow [PDF]
, 2017 In the present study, high data rate measurements were obtained for the streamwise and vertical velocity components using 2D Laser Doppler Velocimeter. The turbulent field in a straight compound-channel flow was characterized for three different uniform ...
Roja-Solórzano, Luís R. +3 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Scientific Reports, 2023 In Fontan patients, a lung deprived of hepatic blood may develop pulmonary arterio-venous malformations (PAVMs) resulting in shunting, reduced pulmonary vascular resistance (PVR) and decreased oxygenation.
Petter Frieberg +4 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
The Effect of Fracturing Fluid Saturation on Natural Gas Flow Behavior in Tight Reservoirs
Energies, 2020 Hydraulic fracturing becomes an essential method to develop tight gas. Under high injection pressure, fracturing fluid entering into the formation will reduce the flow channel.
Mianmo Meng +4 more
doaj +1 more source