Results 161 to 170 of about 4,671 (208)

The rates of saxitoxin action and of saxitoxin-tetrodotoxin interaction at the node of Ranvier

Pfl�gers Archiv European Journal of Physiology, 1975
Voltage clamp experiments were done on single nodes of Ranvier of Rana esculenta. Equilibrium effects were obtained from INa-V curves, the rates of action from changes in INa on changing solutions during repetitive depolarizing pulses. 2. Saxitoxin (STX) exclusively and reversibly blocked Na channels, the effect being fully described by a one-to-one ...
H H, Wagner, W, Ulbricht
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Synthesis of saxitoxins

Pure and Applied Chemistry, 2012
Saxitoxin (STX), a neurotoxin isolated from Alaskan butter clam, Saxidomus giganteus, inhibits voltage-gated sodium channels by binding to the pore-forming p-loop region. Here we describe stereospecific syntheses of STX and its natural derivatives, (+)-decarbamoylsaxitoxin (dcSTX) and (+)-gonyautoxin3 (GTX3).
Osamu Iwamoto, Takafumi Akimoto, Kazuo Nagasawa   +2 more
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Comparative Proteomics Reveals That a Saxitoxin-Producing and a Nontoxic Strain ofAnabaena circinalisAre Two Different Ecotypes

Journal of Proteome Research, 2014
In Australia, saxitoxin production is restricted to the cyanobacterial species Anabaena circinalis and is strain-dependent. We aimed to characterize a saxitoxin-producing and nontoxic strain of A. circinalis at the proteomic level using iTRAQ.
Paul M D'Agostino, Xiaomin Song, Brett A Neilan   +2 more
exaly   +2 more sources

Synthesis of Saxitoxin and Its Derivatives

Organic Letters, 2020
The chiral synthesis of (+)-saxitoxin and its derivatives is described. Two consecutive carbon-nitrogen bonds at C-5 and C-6 in saxitoxin were effectively installed by the sequential Overman rearrangement of an allylic vicinal diol derived from d-malic acid.
Yuya Okuyama, Ryosuke Okamoto, Shori Mukai, Kyoko Kinoshita, Takaaki Sato, Noritaka Chida   +5 more
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Structure of saxitoxin

Journal of the American Chemical Society, 1975
Saxitoxin is a neurotoxin found in various molluscs. The p-bromobenzenesulfonate-saxitoxin was crystallized and the structure was determined by single-crystal x-ray diffraction. Bond distances and angles were discussed, and a computer generated drawing of the final x-ray model was presented. (DDA)
E. J. Schantz, V. E. Ghazarossian, H. K. Schnoes, F. M. Strong, J. P. Springer, John O. Pezzanite, Jon Clardy   +6 more
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Saxitoxin

The surface waters contaminated with cyanobacteria, which are utilized for drinking, irrigation, and recreational purposes, poses a potential hazard to population health, as well as domestic animals and wildlife. Due to the observed trends of rising temperatures and the increased levels of nutrient pollution in surface waters, the occurrence of marine ...
Senanur Ozsoy, Izem Bilinmis, Ayse Nursen Basaran   +2 more
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Derivatives of saxitoxin

Bioorganic Chemistry, 1981
Abstract The preparation, spectral characterization, chromatographic and biological properties of several derivatives of saxitoxin, a highly potent neurotoxin, are described. Derivatives include decarbamoylsaxitoxin, both epimers of dihydrosaxitoxin (α- and β-saxitoxinol) and both epimers of decarbamoylsaxitoxinol, as well as several isotopically ...
Frank E. Koehn, Vartan E. Ghazarossian, E.J. Schantz, H.K. Schnoes, F.M. Strong   +4 more
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Differentiation of the actions of tetrodotoxin and saxitoxin

Toxicon, 1967
Abstract While tetrodotoxin and saxitoxin are very similar in their actions, they can be differentiated biologically by the observation that newts of the genus Taricha are resistant to tetrodotoxin but not to saxitoxin. The resistance of these newts is due to a remarkable insensitivity of the somatic motor nerves to tetrodotoxin.
C Y, Kao, F A, Fuhrman
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Occurrence of saxitoxin in puffer fish

Toxicon, 1984
Three species of puffer fish, Takifugu poecilonotus, T. vermicularis and T. radiatus, were examined for the presence of toxic components other than tetrodotoxin. Saxitoxin, a paralytic shellfish toxin, was found in the livers, ovaries and digestive tracts of the first two species but not in the last species.
M, Nakamura, Y, Oshima, T, Yasumoto
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Chemosensors for the Marine Toxin Saxitoxin

Journal of the American Chemical Society, 2002
Eleven anthracylmethyl crown ethers have been synthesized and evaluated as fluorescence sensors for the marine toxin saxitoxin. Fluorescence enhancement data are consistent with a 1:1 binding complex for all crowns. The binding constants are in the range of 10(4) M(-)(1) in ammonium phosphate buffer (pH 7.1) in 80% ethanol solvent.
Robert E, Gawley, Sandra, Pinet, Claudia M, Cardona, Probal K, Datta, Tong, Ren, Wayne C, Guida, Jason, Nydick, Roger M, Leblanc   +7 more
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