Results 101 to 110 of about 5,948 (206)

Neurofilament light chain is a promising serum biomarker in spinocerebellar ataxia type 3

Molecular Neurodegeneration, 2019
Background Spinocerebellar ataxia type 3 (SCA3) is the most common subtype of autosomal dominantly inherited spinocerebellar ataxias (SCAs). No validated blood biomarker is available to assess either disease progression or therapeutic response ...
Quan-Fu Li, Yi Dong, Lu Yang, Juan-Juan Xie, Yin Ma, Yi-Chu Du, Hao-Ling Cheng, Wang Ni, Zhi-Ying Wu   +8 more
doaj   +1 more source

Peripheral Oxidative Stress Biomarkers in Spinocerebellar Ataxia Type 3/Machado–Joseph Disease

Frontiers in Neurology, 2017
ObjectivesSpinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a polyglutamine disorder with no current disease-modifying treatment. Conformational changes in mutant ataxin-3 trigger different pathogenic cascades, including reactive oxygen ...
Adriano M. de Assis, Adriano M. de Assis, Jonas Alex Morales Saute, Jonas Alex Morales Saute, Jonas Alex Morales Saute, Jonas Alex Morales Saute, Jonas Alex Morales Saute, Aline Longoni, Clarissa Branco Haas, Vitor Rocco Torrez, Andressa Wigner Brochier, Gabriele Nunes Souza, Gabriel Vasata Furtado, Gabriel Vasata Furtado, Tailise Conte Gheno, Tailise Conte Gheno, Aline Russo, Thais Lampert Monte, Thais Lampert Monte, Raphael Machado Castilhos, Artur Schumacher-Schuh, Artur Schumacher-Schuh, Rui D’Avila, Karina Carvalho Donis, Carlos Roberto de Mello Rieder, Carlos Roberto de Mello Rieder, Carlos Roberto de Mello Rieder, Diogo Onofre Souza, Diogo Onofre Souza, Suzi Camey, Suzi Camey, Vanessa Bielefeldt Leotti, Vanessa Bielefeldt Leotti, Laura Bannach Jardim, Laura Bannach Jardim, Laura Bannach Jardim, Laura Bannach Jardim, Laura Bannach Jardim, Luis Valmor Portela, Luis Valmor Portela   +39 more
doaj   +1 more source

Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Molecular Neurodegeneration, 2018
Background Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by expansion of the polyglutamine repeat in the ataxin-3 protein.
Lodewijk J. A. Toonen, Maurice Overzier, Melvin M. Evers, Leticia G. Leon, Sander A. J. van der Zeeuw, Hailiang Mei, Szymon M. Kielbasa, Jelle J. Goeman, Kristina M. Hettne, Olafur Th. Magnusson, Marion Poirel, Alexandre Seyer, Peter A. C. ‘t Hoen, Willeke M. C. van Roon-Mom   +13 more
doaj   +1 more source

RNA Expression Profile and Potential Biomarkers in Patients With Spinocerebellar Ataxia Type 3 From Mainland China

Frontiers in Genetics, 2019
Long non-coding RNAs (lncRNAs) play an important role in growth, development, and reproduction and undoubtedly contribute to the pathogenesis and progression of diseases.
Tianjiao Li, Xiaocan Hou, Zhao Chen, Yun Peng, Puzhi Wang, Yue Xie, Lang He, Hongyu Yuan, Huirong Peng, Rong Qiu, Kun Xia, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang   +18 more
doaj   +1 more source

Spinocerebellar ataxia type 3 (SCA3): Thalamic neurodegeneration occurs independently from thalamic ataxin-3 immunopositive neuronal intranuclear inclusions

, 2006
n the last years progress has been made regarding the involvement of the thalamus during the course of the currently known polyglutamine diseases. Although recent studies have shown that the thalamus consistently undergoes neurodegeneration in Huntington'
Paulson, Henry, Schols, Ludger, Bohl, Juergen, Sebesteny, Tamas, Heinsen, Helmut, de Vos, Rob A. I., Schoels, Ludger, Rueb, Udo, Den Dunnen, Wilfrid, De Vos, Rob A.I., Auburger, Georg, Gierga, Kristin, Seidel, Kay, den Dunnen, Wilfred; id_orcid, Bohl, Jurgen, Ghebremedhin, Estifanos, Rub, Udo, Deller, Thomas, Brunt, Ewout R., den Dunnen, Wilfred   +19 more
core   +2 more sources

Gait features of PD and SCA3 and corresponding gait parameters computed by FLLIT.

, 2019
Gait features of PD and SCA3 and corresponding gait parameters computed by FLLIT.
Kah Junn Tan (3164907), Lakshmi Narasimhan Govindarajan (6889274), Sherry Shiying Aw (6889289), Camilo Libedinsky (3324999), Malvika Katarya (6889283), Lin Gu (1306755), Daiqin Li (150360), Li Cheng (228291), Boon Hui Wong (6889286), Shuang Wu (148427), James Charles Stewart (6889277), Adam Claridge-Chang (61993), Eng-King Tan (283980), Joses Wei Hao Ho (6889280)   +13 more
core   +1 more source

Gene-Related Cerebellar Neurodegeneration in SCA3/MJD: A Case-Controlled Imaging-Genetic Study

Frontiers in Neurology, 2019
Background: Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is one of the nine polyglutamine (polyQ) diseases and is caused by a CAG repeat expansion within the coding sequence of the ATXN3 gene.
Huirong Peng, Xiaochun Liang, Zhe Long, Zhao Chen, Yuting Shi, Kun Xia, Li Meng, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Rong Qiu, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang   +19 more
doaj   +1 more source

Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model. [PDF]

Inhibition of acetylcholinesterase (AChE) is a common used treatment option for Alzheimer’s disease. However, there has been limited research on the potential use of AChE inhibitors for the treatment of Machado-Joseph disease (MJD)/Spinocerebellar Ataxia
Pohl, Franziska, Teixeira-Castro, Andreia, Kong Thoo Lin, Paul, Lindsay-McGee, Victoria, Maciel, Patricia, Lindsay-McGee, Victoria; id_orcid   +5 more
core   +1 more source

Disfunção executiva na ataxia espinocerebelar tipo 3 - SCA3

, 2019
Dissertação (mestrado)—Universidade de Brasília, Instituto de Psicologia, Departamento de Processos Psicológicos Básicos, Programa de Pós-Graduação em Ciências do Comportamento, 2019.A pesquisa teve como objetivo avaliar as funções executivas por meio de
Freitas, Luciana de Figueiredo Pereira
core  

Estudio neurofisiológico multimodal en las ataxias espinocerebelosas con herencia autosómica dominante de tipo SCA2 y SCA3

Neurología, 2011
Resumen: Introducción: Las ataxias espinocerebelosas (SCA) son un grupo de enfermedades neurodegenerativas genética, clínica y patológicamente heterogéneo, caracterizado por presentar una ataxia cerebelosa lentamente progresiva.
S. Álvarez-Paradelo, A. García, J. Infante, J. Berciano   +3 more
doaj   +1 more source