Results 81 to 90 of about 5,948 (206)

Enhancing the fastness characteristics of weld‐dyed cotton and recycled nylon 6,6 fabrics via sodium alginate and titanium dioxide

Coloration Technology, EarlyView.
Abstract This study investigates a sustainable dyeing and finishing strategy for recycled nylon 6,6 and organic cotton fabrics dyed with weld. Following meta‐mordant dyeing using alum under Natural Organic Dye Standard (NODS)‐compliant conditions, the fabrics were subjected to functional finishing with titanium dioxide as a multifunctional ...
Recep Karadag, Fatma Zehra Engin Sagirli, Abdulkadir Pars   +2 more
wiley   +1 more source

Expanded ATXN3 allele is expressed in differentiated SCA3 lt-NES cells.

, 2018
Western blot analysis of wild type ATXN3 (approx.50 kD, thin arrow) expressed in both the controls and the SCA3 cells, and the expanded, mutant ATXN3 protein (approx.70 kD, thick arrow) in the SCA3 cells.
Bernd O. Evert (5608034), Johannes Jungverdorben (5608037), Frank Matthes (598149), Rohit Nalavade (4730508), Ashish Rajput (269079), Stephanie Weber (704618), Stefan Bonn (2619949), Michael Peitz (4805655), Sybille Krauß (258847), Oliver Brüstle (147363)   +9 more
core   +1 more source

Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation

Aging, 2020
Polyglutamine (polyQ)-mediated spinocerebellar ataxias (SCA) are caused by mutant genes with expanded CAG repeats encoding polyQ tracts. The misfolding and aggregation of polyQ proteins result in increased reactive oxygen species (ROS) and cellular toxicity.
Chiu, Ya-Jen, Lin, Shu-An, Chen, Wan-Ling, Lin, Te-Hsien, Lin, Chih-Hsin, Yao, Ching-Fa, Lin, Wenwei, Wu, Yih-Ru, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen, Chen, Chiung-Mei   +10 more
openaire   +2 more sources

Impaired Lower Limb Proprioception in Spinocerebellar Ataxia Type 3 and Its Affected Factors

Frontiers in Neurology, 2022
BackgroundSpinocerebellar ataxia type 3 (SCA3) is one of the most common hereditary neurodegenerative diseases. Postural control dysfunction is the main symptom of SCA3, and the proprioceptive system is a critical sensory component of postural control ...
Xia-Hua Liu, Zhi-Yong Wang, Ying Li, Hao-Ling Xu, Arif Sikandar, Jun Ni, Shi-Rui Gan   +6 more
doaj   +1 more source

Modulation of the Stress Granule Component Carhsp1 Mitigates Disease‐Associated Deficits in Spinocerebellar Ataxia Type 3 Mouse Models

Movement Disorders, Volume 41, Issue 6, Page 1516-1527, June 2026.
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) neurogenerative disorder that results from CAG trinucleotide repeat expansions in the ATXN3 gene, leading to toxic protein aggregate formation and cellular pathway dysfunction.
Tiago Moreira‐Gomes, Adriana Marcelo, Ana Teresa Rajado, Rafael G. Costa, Ricardo Afonso‐Reis, Cristiana R. Madeira, Inês T. Afonso, David V.C. Brito, Adriana A. Vaz, Clévio Nóbrega   +9 more
wiley   +1 more source

Pathoanatomy of Cerebellar Degeneration in Spinocerebellar Ataxia Type 2 (SCA2) and Type 3 (SCA3)

, 2012
The cerebellum is one of the well-known targets of the pathological processes underlying spinocerebellar ataxia type 2 (SCA2) and type 3 (SCA3). Despite its pivotal role for the clinical pictures of these polyglutamine ataxias, no pathoanatomical studies
Rueb, U., de Vos, R. A., Auburger, G., Buerk, K., Korf, H. W., den Dunnen, W. F.; id_orcid, Brunt, E. R., Deller, T., Schoels, L., Seidel, K., Scherzed, W., Heinsen, H., Del Turco, D., den Dunnen, W. F.   +13 more
core   +1 more source

Extra-Cerebellar Signs and Non-motor Features in Chinese Patients With Spinocerebellar Ataxia Type 3

Frontiers in Neurology, 2019
Objectives: Our study attempted to systematically explore the prevalence of extra-cerebellar signs and non-motor symptoms, such as anxiety, depression, fatigue, excessive daytime sleepiness (EDS) and sleep disturbances in a cohort of Chinese patients ...
Xiaoqin Yuan, Ruwei Ou, Yanbing Hou, Xueping Chen, Bei Cao, Xun Hu, Huifang Shang   +6 more
doaj   +1 more source

Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins

The FEBS Journal, Volume 293, Issue 11, Page 3376-3398, June 2026.
Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak, Martina Sollazzo, Elisa Monaca, Raffaele Sabbatella, Maria Agnese Morando, Oleg Chertkov, Laura Puglisi, Martina Mascellino, Anna Fricano, Sandra Macedo‐Ribeiro, Caterina Alfano   +10 more
wiley   +1 more source

No parkinsonism in SCA2 and SCA3 despite severe neurodegeneration of the dopaminergic substantia nigra

, 2015
The spinocerebellar ataxias types 2 (SCA2) and 3 (SCA3) are autosomal dominantly inherited cerebellar ataxias which are caused by CAG trinucleotide repeat expansions in the coding regions of the disease-specific genes.
Reischl, Gerald, Schoels, Ludger, Globas, Christoph, Rueb, Udo, Brockmann, Kathrin, Hauser, Till Karsten, Reimold, Matthias, Auburger, Georg, Korf, Horst-Werner, Seidel, Kay, den Dunnen, Wilfred; id_orcid, Buerk, Katrin, Brunt, Ewout R., den Dunnen, Wilfred   +13 more
core   +1 more source

Deficiency in classical nonhomologous end-joining–mediated repair of transcribed genes is linked to SCA3 pathogenesis [PDF]

, 2020
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disease caused by CAG (encoding glutamine) repeat expansion in the Ataxin-3 (ATXN3) gene.
Tapryal, Nisha, Mitra, Joy, Sarker, Altaf H, Venkova, Tatiana, Ashizawa, Tetsuo, Duarte-Silva, Sara, Sarkar, Partha S, Ghosh, Gourisankar, Chen, Xu, Hazra, Tapas K, Huai, Weihan, Chakraborty, Anirban, Hegde, Muralidhar L, Vasquez, Velmarini, Maciel, Patricia   +14 more
core   +1 more source