Results 111 to 120 of about 3,473,693 (329)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Rvi15 (Vr2) Apple Scab Resistance Locus Contains Three TIR-NBS-LRR Genes

Molecular Plant-Microbe Interactions, 2010
Scab caused by the pathogen Venturia inaequalis is considered the most important fungal disease of cultivated apple (Malus × domestica Borkh.). In all, 16 monogenic resistances against scab have been found in different Malus spp.
Paolo Galli, Andrea Patocchi, Giovanni Antonio Lodovico Broggini, Cesare Gessler   +3 more
doaj   +1 more source

The Organic Research Centre - Elm Farm:Bulletin 87 [PDF]

, 2007
Bulletin 87 with coverage of Avian Influenza H5N1 in Suffolk,commentary on Biofuels, a paper on the organic "transition to sustainable resilience",paper on participatory approach to agronomy trials,update on evolutionary breeding of wheat project,article
Fleming, D, Hinchsliffe, K, Hitchings, R, Jones, Dr H, Sanders, R, Woodward, L   +5 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Anatomical study of the leaves and petioles of scab resistant and susceptible apple cultivars

International Journal of Horticultural Science, 2005
Anatomic studies have been performed on the leaf blade, petiole and annual shoot on six apple cultivars by means of scanning electron as well as light microscope.
M. Tóth, P. Gracza
doaj   +1 more source

An assessment of apple varieties for their suitability in organic production systems [PDF]

, 2008
Twenty seven varieties of apple were assessed for their susceptibility to apple scab, mildew and rosy apple aphid in a replicated experiment at East Malling Research.
Berrie, A., Cross, J., Cubison, S., Fitzgerald, J.   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Transcriptome analysis under pecan scab infection reveals the molecular mechanisms of the defense response in pecans.

PLoS ONE
Pecan scab, caused by the fungal pathogen Venturia effusa, is the most devastating disease of pecan (Carya illinoinensis) in the southeastern United States.
Gaurab Bhattarai, Hormat Shadgou Rhein, Avinash Sreedasyam, John T Lovell, Sameer Khanal, Jane Grimwood, Jeremy Schmutz, Jerry Jenkins, Peng W Chee, Cristina Pisani, Jennifer Randall, Patrick J Conner   +11 more
doaj   +1 more source

High-density Linkage Mapping and Identification of Quantitative Trait Loci Associated with Scab Resistance in Pecan

Journal of the American Society for Horticultural Science
Genetic maps are essential tools for gene positional cloning and marker-assisted breeding. A pecan (Carya illinoinensis) mapping population of 119 F1 trees was developed from a cross of the widely planted cultivars ‘Pawnee’ and ‘Elliott’. Whereas ‘Pawnee’
Gaurab Bhattarai, Shanshan Cao, Nolan Bentley, Patricia Klein, Clive H. Bock, Cristina Pisani, Patrick J. Conner   +6 more
doaj   +1 more source