Results 101 to 110 of about 4,820 (256)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Characterization of Olive-Resistant Genes Against Spilocaea oleagina, the Causal Agent of Scab

Agronomy
The olive tree (Olea europaea subsp. europaea L.) is one of the most important perennial crops in the Mediterranean Basin. Olive Scab, caused by the fungal species Spilocaea oleagina, a member of the Venturiaceae family, is among the most significant ...
Cristina Estudillo, Adrián Pérez-Rial, Francisco Abel Guerrero-Páez, Concepción M. Díez, Juan Moral, José V. Die   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Breeding a New Apple Hybrid Population with the Vf Gene Through Marker-Assisted Selection

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Horticulture
Apple scab, caused by Venturia inaequalis, is one of the most damaging pathogens affecting apple species. Cross combinations were made between the Salva cv. (female parent), a valuable local cultivar known for its fruit quality and used as a donor of the
Georgeta Maria BIVOLARIU (GUZU), Ioan ZAGRAI, Claudiu MOLDOVAN, Smaranda Doina ROȘU MAREȘ, Anca Maria CHIOREAN, Luminița Antonela ZAGRAI, Mirela Irina CORDEA   +6 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

ANALYSIS OF GENETIC POLYMORPHISM FOR SCAB RESISTANT COWPEA VARIETIES USING SSR AND SNP MARKERS

Journal of Experimental and Molecular Biology
Cowpea scab disease, caused by Sphaceloma sp., significantly reduces yield. This study screened nine cowpea varieties for resistance to scab using both phenotypic and molecular markers (SSR and SNP).
Joseph Olasan Olalekan, Celestine Uzoma Aguoru, Amos Abama Joshua, Ekeruo Godspower Chibuike, Ugbaa Macsamuel Sesugh   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Metabolomic datasets of an apple progeny carrying resistance quantitative trait loci to apple scab before or after inoculation of the pathogen Venturia inaequalisentrepot.recherche.data.gouv.fr

Data in Brief
Phytosanitary treatments are massively used in orchards to fight apple scab, a disease caused by the fungus Venturia inaequalis (Vi). To reduce these treatments, resistant varieties are largely deployed but their effectiveness can decrease over time. The
Romane Lapous, Florent Magot, Romain Larbat, Caroline Denancé, Christian Cattanéo, Hélène Muranty, Charles-Eric Durel, Julie Ferreira de Carvalho   +7 more
doaj   +1 more source