Results 81 to 90 of about 4,820 (256)

Molecular marker analysis of genes of resistance to scab and fire blight in the apple cultivars bred at the Sverdlovsk Horticultural Breeding Station

Биотехнология и селекция растений
Background. Unique apple cultivars have been created at the Sverdlovsk Horticultural Breeding Station and adapted to growing in the harsh natural and climatic conditions of the Middle Urals.
I. N. Shamshin, D D. Telezhinskiy, A. V. Shlyavas   +2 more
doaj   +1 more source

Rvi4 and Rvi15 are the same apple scab resistance genes. [PDF]

Mol Breed, 2023
Peil A, Howard NP, Bühlmann-Schütz S, Hiller I, Schouten H, Flachowsky H, Patocchi A.   +6 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Development of 'Poroshiri', a chip processing potato variety with golden cyst nematode and common scab resistance. [PDF]

Breed Sci, 2023
Tsuyama M, Ogawa S, Ogawa K, Igarashi T, Koizumi E.   +4 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Chromosome-level phased genome assembly of "Antonovka" identified candidate apple scab-resistance genes highly homologous to HcrVf2 and HcrVf1 on linkage group 1. [PDF]

G3 (Bethesda), 2023
Švara A, Sun H, Fei Z, Khan A.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Marker selection of promising varietal and breeding material of apple tree

RUDN Journal of Agronomy and Animal Industries
Apple tree ( Malus × domestica Borkh.) is a leading agricultural pome crop, one of the main perennial fruit plants in the world, commercially in demand and widespread in the horticultural industry of Russia, including the North Caucasus region.
Elena V. Ulianovskaya, Tatyana V. Chernutskaya, Evgeniya A. Bogdanovich, Sergey V. Tokmakov, Ilya V. Stepanov   +4 more
doaj   +1 more source

Successful intergeneric transfer of a major apple scab resistance gene (Rvi6) from apple to pear and precise comparison of the downstream molecular mechanisms of this resistance in both species. [PDF]

BMC Genomics, 2021
Perchepied L, Chevreau E, Ravon E, Gaillard S, Pelletier S, Bahut M, Berthelot P, Cournol R, Schouten HJ, Vergne E.   +9 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source