Results 71 to 80 of about 4,820 (256)

Anatomical study of the leaves and petioles of scab resistant and susceptible apple cultivars

International Journal of Horticultural Science, 2005
Anatomic studies have been performed on the leaf blade, petiole and annual shoot on six apple cultivars by means of scanning electron as well as light microscope.
M. Tóth, P. Gracza
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

High-density Linkage Mapping and Identification of Quantitative Trait Loci Associated with Scab Resistance in Pecan

Journal of the American Society for Horticultural Science
Genetic maps are essential tools for gene positional cloning and marker-assisted breeding. A pecan (Carya illinoinensis) mapping population of 119 F1 trees was developed from a cross of the widely planted cultivars ‘Pawnee’ and ‘Elliott’. Whereas ‘Pawnee’
Gaurab Bhattarai, Shanshan Cao, Nolan Bentley, Patricia Klein, Clive H. Bock, Cristina Pisani, Patrick J. Conner   +6 more
doaj   +1 more source

The Rvi15 (Vr2) Apple Scab Resistance Locus Contains Three TIR-NBS-LRR Genes

Molecular Plant-Microbe Interactions, 2010
Scab caused by the pathogen Venturia inaequalis is considered the most important fungal disease of cultivated apple (Malus × domestica Borkh.). In all, 16 monogenic resistances against scab have been found in different Malus spp.
Paolo Galli, Andrea Patocchi, Giovanni Antonio Lodovico Broggini, Cesare Gessler   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Homologue of HcrVf genes from pear genome

Фактори експериментальної еволюції організмів, 2013
Aims. The aim of this research was isolation and structure analysis of the sequence homologous to HcrVf genes, which associated with resistant to apple scab, from pear genome resistant to scab. Methods.
O. Yu. Urbanovich, P. V. Kuzmitskaya, Z. A. Kazlovskaya, B. Yu. Anoshenko   +3 more
doaj  

Revealing Key Genes and Pathways in Potato Scab Disease Resistance through Transcriptome Analysis

Agronomy
Potato scab, a global soil-borne disease caused by Streptomyces, is pivotal in developing resistant cultivars due to its complex resistance mechanisms. This study investigates the transcriptomic responses in potato to common scab using resistant variety ...
Chuang Li, Baoqi Yuan, Chuan Zhang, Qi Yao, Hongxia He, Qingfeng Wang, Jinping Liang, Nan Li, Xu Zhu, Zhongwei Wang   +9 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Transcriptome analysis under pecan scab infection reveals the molecular mechanisms of the defense response in pecans.

PLoS ONE
Pecan scab, caused by the fungal pathogen Venturia effusa, is the most devastating disease of pecan (Carya illinoinensis) in the southeastern United States.
Gaurab Bhattarai, Hormat Shadgou Rhein, Avinash Sreedasyam, John T Lovell, Sameer Khanal, Jane Grimwood, Jeremy Schmutz, Jerry Jenkins, Peng W Chee, Cristina Pisani, Jennifer Randall, Patrick J Conner   +11 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source