The ECM: To Scaffold, or Not to Scaffold, That Is the Question [PDF]
The extracellular matrix (ECM) has pleiotropic effects, ranging from cell adhesion to cell survival. In tissue engineering, the use of ECM and ECM-like scaffolds has separated the field into two distinct areas—scaffold-based and scaffold-free. Scaffold-free techniques are used in creating reproducible cell aggregates which have massive potential for ...
Jonard C Valdoz, Van Ry Pam
exaly +3 more sources
The selection and application of design methodologies for the design of bone tissue scaffolds [PDF]
Research motivation: Bone tissue scaffolds offer a way forward in a strategy to change from tissue replacement to tissue regeneration. Bone tissue scaffolds are a combination of a physical construct, with clearly defined three-dimensional spatial ...
Blogg, Ken
core +7 more sources
An Experimental Study of Porous Hydroxyapatite Scaffold Bioactivity in Biomedical Applications [PDF]
Hydroxyapatite is one of the most bioactive materials used in tissue engineering due to its excellent biocompatibility and chemical composition which is equivalent to the mineral element of bone.
Auday Mehatlaf, Alaa Atiyah, Saad Farid
doaj +1 more source
Decellularization of tissues and organs has recently become a promising approach in tissue engineering and regenerative medicine to circumvent the challenges of organ donation and complications of transplantations.
Radman Mazloomnejad +6 more
doaj +1 more source
Scaffold Generator - A Java library implementing molecular scaffold functionalities in the Chemistry Development Kit (CDK) [PDF]
The concept of molecular scaffolds as defining core structures of organic molecules is utilised in many areas of chemistry and cheminformatics, e.g. drug design, chemical classification, or the analysis of high-throughput screening data. Here, we present
Julian, Zander +3 more
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Composite mesoporous vaterite-magnetite coatings on polycaprolactone fibrous matrix [PDF]
Background and Objectives: Based on polymers and inorganic components, hybrid nanostructured materials are used in biomedicine, including tissue engineering and drug delivery with the controlled release.
Koronevskiy, Nikita Vladimirovich +5 more
doaj +1 more source
ERK Signals: Scaffolding Scaffolds? [PDF]
ERK1/2 MAP Kinases become activated in response to multiple intra- and extra-cellular stimuli through a signaling module composed of sequential tiers of cytoplasmic kinases. Scaffold proteins regulate ERK signals by connecting the different components of the module into a multi-enzymatic complex by which signal amplitude and duration are fine-tuned ...
Casar, Berta, Crespo, Piero
openaire +4 more sources
The Scaffold Tree − Visualization of the Scaffold Universe by Hierarchical Scaffold Classification [PDF]
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ansgar Schuffenhauer +5 more
openaire +3 more sources
Bioactive Inks Development for Osteochondral Tissue Engineering: A Mini-Review
Nowadays, a prevalent joint disease affecting both cartilage and subchondral bone is osteoarthritis. Osteochondral tissue, a complex tissue unit, exhibited limited self-renewal potential.
Negar Bakhtiary +2 more
doaj +1 more source
Identification of Bioisosteric Scaffolds using Scaffold Keys [PDF]
Replacement of a central scaffold in a bioactive molecule by another scaffold with similar structural features (a procedure called sometimes "scaffold hopping") is a classical medicinal chemistry technique used to improve molecular properties and explore
Peter, Ertl
core +1 more source

