Results 31 to 40 of about 349,978 (268)

Injectable skeletal muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model [PDF]

European Cells & Materials, 2012
Peripheral artery disease (PAD) currently affects approximately 27 million patients in Europe and North America, and if untreated, may progress to the stage of critical limb ischemia (CLI), which has implications for amputation and potential mortality ...
JA DeQuach, JE Lin, C Cam, D Hu, MA Salvatore, F Sheikh, KL Christman   +6 more
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Design and development of a fibrous structure for the potential treatment of spinal cord injury using parametric modelling in Rhinoceros 3D®

AUTEX Research Journal
Spinal cord injury (SCI) consists of partial or complete damage to the organ’s functions. Injuries can be traumatic or non-traumatic. New investigations have pointed out different paths in terms of spinal cord regeneration.
de Aguiar Souza Ivis, Kohan Lais, Rocha Joana M., da Silva Filho Maurício José, Peixoto Joaquim Jorge, Fangueiro Raul, Ferreira Diana S. P.   +6 more
doaj   +1 more source

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Pharmaceutics
This comprehensive review consolidates insights from two sources to emphasize the transformative impact of scaffold-based drug delivery systems in revolutionizing oral cancer therapy.
Elham Saberian, Andrej Jenča, Adriána Petrášová, Hadi Zare-Zardini, Meysam Ebrahimifar   +4 more
doaj   +1 more source

Promoting external inosculation of prevascularised tissue constructs by pre-cultivation in an angiogenic extracellular matrix [PDF]

European Cells & Materials, 2010
The engineering of preformed microvessels offers the promising opportunity to rapidly vascularise implanted tissue constructs by the process of inosculation.
D Eglin, M Alini, MD Menger, H Mussawy, S Schuler, MW Laschke   +5 more
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Cell-scaffold interactions in the bone tissue engineering triad [PDF]

European Cells & Materials, 2013
Bone tissue engineering has emerged as one of the leading fields in tissue engineering and regenerative medicine. The success of bone tissue engineering relies on understanding the interplay between progenitor cells, regulatory signals, and the ...
CM Murphy, FJ O’Brien, DG Little, A Schindeler   +3 more
doaj  

Research progress on injectable hydrogel scaffolds in dental pulp regeneration

口腔疾病防治, 2022
Tissue engineering provides a new possibility for pulp regeneration. As one of the three elements of tissue engineering, scaffolds have attracted increasing attention.
FANG Na, LI Xiangwei
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source