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Cell-based bone tissue engineering. [PDF]

PLoS Medicine, 2007
The authors review the available data on bone tissue engineering and discuss possible new research areas that could help to make bone tissue engineering a clinical success.
Gert J Meijer, Joost D de Bruijn, Ron Koole, Clemens A van Blitterswijk   +3 more
doaj   +9 more sources

Bioprinting for bone tissue engineering

Frontiers in Bioengineering and Biotechnology, 2022
The shape transformation characteristics of four-dimensional (4D)-printed bone structures can meet the individual bone regeneration needs, while their structure can be programmed to cross-link or reassemble by stimulating responsive materials.
Xin Kang, Xiao-Bo Zhang, Xi-Dan Gao, Ding-Jun Hao, Tao Li, Zheng-Wei Xu   +5 more
doaj   +3 more sources

3D printing of bone tissue engineering scaffolds

Bioactive Materials, 2020
Tissue engineering is promising in realizing successful treatments of human body tissue loss that current methods cannot treat well or achieve satisfactory clinical outcomes.
Chong Wang, Wei Huang, Yu Zhou, Libing He, Zhi He, Ziling Chen, Xiao He, Shuo Tian, Jiaming Liao, Bingheng Lu, Yen Wei, Min Wang   +11 more
doaj   +3 more sources

Magnetic Nanoparticles in Bone Tissue Engineering

Nanomaterials, 2022
Large bone defects with limited intrinsic regenerative potential represent a major surgical challenge and are associated with a high socio-economic burden and severe reduction in the quality of life. Tissue engineering approaches offer the possibility to
Akshith Dasari, Jingyi Xue, Sanjukta Deb
doaj   +3 more sources

Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis

Frontiers in Endocrinology, 2022
Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone microarchitecture, with an increased risk of fractures. Classical theories hold that osteoporosis is essentially a bone remodeling disorder caused by estrogen ...
Weidong Zhang, Weidong Zhang, Ruihan Gao, Ruihan Gao, Xing Rong, Xing Rong, Siqi Zhu, Siqi Zhu, Yajun Cui, Yajun Cui, Hongrui Liu, Hongrui Liu, Minqi Li, Minqi Li   +13 more
doaj   +1 more source

Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis

Frontiers in Pharmacology, 2023
Bone tissue engineering (BTE) has become a hopeful potential treatment strategy for large bone defects, including bone tumors, trauma, and extensive fractures, where the self-healing property of bone cannot repair the defect.
Jun Liu, Lili Yang, Kexin Liu, Feng Gao
doaj   +1 more source

New insight of immuno-engineering in osteoimmunomodulation for bone regeneration

Regenerative Therapy, 2021
With the continuous development of bone tissue engineering, the importance of immune response in bone tissue regeneration is gradually recognized.
Long Ouyang, Jiankun Cao, Qiang Dai, Daojing Qiu   +3 more
doaj   +1 more source

Exendin-4 and eldecalcitol synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells through M2 macrophages polarization via PI3K/AKT pathway

Stem Cell Research & Therapy, 2022
Background The incidence of diabetic osteoporosis is increasing. This article evaluates the effect of combination treatment with the hypoglycemic drug exendin-4 (Ex-4) and the vitamin D analog eldecalcitol (ED-71) on improving diabetic osteoporosis and ...
Yupu Lu, Shanshan Liu, Panpan Yang, Yuying Kou, Congshan Li, Hongrui Liu, Minqi Li   +6 more
doaj   +1 more source

Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications

Frontiers in Cell and Developmental Biology, 2022
Treatment of bone defects remains a challenge in the clinic. Artificial bone grafts are the most promising alternative to autologous bone grafting. However, one of the limiting factors of artificial bone grafts is the limited means of regulating stem ...
Yuyang Sun, Ben Wan, Ben Wan, Renxian Wang, Bowen Zhang, Peng Luo, Diaodiao Wang, Jing-Jun Nie, Dafu Chen, Xinbao Wu   +9 more
doaj   +1 more source

Prevention of sclerosis around cannulated screw after treatment of femoral neck fractures with bioceramic nails: a finite element analysis

BMC Musculoskeletal Disorders, 2023
Purpose Conventional cannulated screws (CS) are the main treatment method for femoral neck fractures (FNF). However, the rate of femoral head necrosis remains high after FNF treatment.
Yang Liu, Yugang Xing, Huifeng Shao, Xiaogang Wu, Yongsheng Ma, Wenming Yang, Qitai Lin, Pengcui Li, Yong He, Wangping Duan, Xiaochun Wei   +10 more
doaj   +1 more source