Results 51 to 60 of about 512,987 (302)

Injectable skeletal muscle matrix hydrogel promotes neovascularization and muscle cell infiltration in a hindlimb ischemia model [PDF]

European Cells & Materials, 2012
Peripheral artery disease (PAD) currently affects approximately 27 million patients in Europe and North America, and if untreated, may progress to the stage of critical limb ischemia (CLI), which has implications for amputation and potential mortality ...
JA DeQuach, JE Lin, C Cam, D Hu, MA Salvatore, F Sheikh, KL Christman   +6 more
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Design and development of a fibrous structure for the potential treatment of spinal cord injury using parametric modelling in Rhinoceros 3D®

AUTEX Research Journal
Spinal cord injury (SCI) consists of partial or complete damage to the organ’s functions. Injuries can be traumatic or non-traumatic. New investigations have pointed out different paths in terms of spinal cord regeneration.
de Aguiar Souza Ivis, Kohan Lais, Rocha Joana M., da Silva Filho Maurício José, Peixoto Joaquim Jorge, Fangueiro Raul, Ferreira Diana S. P.   +6 more
doaj   +1 more source

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Pharmaceutics
This comprehensive review consolidates insights from two sources to emphasize the transformative impact of scaffold-based drug delivery systems in revolutionizing oral cancer therapy.
Elham Saberian, Andrej Jenča, Adriána Petrášová, Hadi Zare-Zardini, Meysam Ebrahimifar   +4 more
doaj   +1 more source

Promoting external inosculation of prevascularised tissue constructs by pre-cultivation in an angiogenic extracellular matrix [PDF]

European Cells & Materials, 2010
The engineering of preformed microvessels offers the promising opportunity to rapidly vascularise implanted tissue constructs by the process of inosculation.
D Eglin, M Alini, MD Menger, H Mussawy, S Schuler, MW Laschke   +5 more
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Research progress on injectable hydrogel scaffolds in dental pulp regeneration

口腔疾病防治, 2022
Tissue engineering provides a new possibility for pulp regeneration. As one of the three elements of tissue engineering, scaffolds have attracted increasing attention.
FANG Na, LI Xiangwei
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Cell-scaffold interactions in the bone tissue engineering triad [PDF]

European Cells & Materials, 2013
Bone tissue engineering has emerged as one of the leading fields in tissue engineering and regenerative medicine. The success of bone tissue engineering relies on understanding the interplay between progenitor cells, regulatory signals, and the ...
CM Murphy, FJ O’Brien, DG Little, A Schindeler   +3 more
doaj  

Changes in the Molecular Characteristics of Bovine and Marine Collagen in the Presence of Proteolytic Enzymes as a Stage Used in Scaffold Formation

Marine Drugs, 2021
Biopolymers, in particular collagen and fibrinogen, are the leading materials for use in tissue engineering. When developing technology for scaffold formation, it is important to understand the properties of the source materials as well as the mechanisms
Marfa N. Egorikhina, Ludmila L. Semenycheva, Victoria O. Chasova, Irina I. Bronnikova, Yulia P. Rubtsova, Evgeniy A. Zakharychev, Diana Ya. Aleynik   +6 more
doaj   +1 more source