Results 71 to 80 of about 512,987 (302)
, 2019 We present a method for visualizing and navigating large screening datasets while also taking into account their activities and properties. Our approach is to annotate the data with all possible scaffolds contained within each molecule. We have developed
Dac-Trung Nguyen (2401174) +19 more
core +1 more source
Advances in Plant-Derived Scaffold Proteins
Frontiers in Plant Science, 2020 Scaffold proteins form critical biomatrices that support cell adhesion and proliferation for regenerative medicine and drug screening. The increasing demand for such applications urges solutions for cost effective and sustainable supplies of ...
Congyue Annie Peng +2 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
The development of a ε-polycaprolactone (PCL) scaffold for CNS repair [PDF]
, 2013 Potential treatment strategies for the repair of spinal cord injury (SCI) currently favour a combinatorial approach incorporating several factors, including exogenous cell transplantation and biocompatible scaffolds. The use of scaffolds for bridging the
Boomkamp, S.D. +13 more
core +1 more source
, 2022 Chen, WilfredModern metabolic engineering uses platform organisms such as E. coli and S. cerevisiae to produce a variety of chemical compounds valuable to various industrial areas such as medical and food/flavor.
Mitkas, Alexander A.
core +1 more source
Journal of Stem Cell Research and Tissue Engineering, 2019 Bone defects due to trauma, tumors, congenital abnormalities, degeneration and other diseases are still major problems in the field of orthopedics and traumatology.
ludita indrio
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
, 2018 a) When sets of three proteins can form a complex and two of them also bind to lipids, localization is again capable of driving stronger complex formation.
Margaret E. Johnson (413090) +1 more
core +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source