Results 91 to 100 of about 735,053 (299)

Functionally gradient tissue scaffold design and deposition path planning for bio-additive processes [PDF]

, 2013
A layer-based tissue scaffold is designed with heterogeneous internal architecture. The proposed layer-based design uses a bi-layer pattern of radial and spiral layer consecutively to generate functionally gradient porosity following the geometry of the ...
Khoda, AKM Bashirul, Koç, Bahattin, Özbolat, İbrahim T.   +2 more
core  

SLS Fabrication of Highly Porous Model Including Fine Flow Channel Network Aiming at Regeneration of Highly Metabolic Organs [PDF]

, 2006
Fabrication of very porous scaffold for regeneration of highly metabolic organs is reported. Polycaprolactone (PCL) powder was mixed with fine salt grains as filler and SLS processed to develop a model including fine flow channel network.
Huang, Hongyun, Naruke, Hiromichi, Niino, Toshiki, Sakai, Yasuyuki   +3 more
core   +1 more source

3D Graphene Scaffolds for Skeletal Muscle Regeneration: Future Perspectives

Frontiers in Bioengineering and Biotechnology, 2020
Although skeletal muscle can regenerate after injury, in chronic damages or in traumatic injuries its endogenous self-regeneration is impaired.
Valentina Palmieri, Valentina Palmieri, Francesca Sciandra, Manuela Bozzi, Marco De Spirito, Marco De Spirito, Massimiliano Papi, Massimiliano Papi   +7 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Meniscus-derived matrix scafolds promote the integrative repair of meniscal defects [PDF]

, 2019
Meniscal tears have a poor healing capacity, and damage to the meniscus is associated with significant pain, disability, and progressive degenerative changes in the knee joint that lead to osteoarthritis.
DeFrate, Louis E., Glass, Katherine A., Guilak, Farshid, McNulty, Amy L., Nishimuta, James F., Rowland, Christopher R., Ruprecht, Jacob C., Stencel, Jennifer, Waanders, Taylor D., Weinberg, J. Brice   +9 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Engineering human cell-based, functionally integrated osteochondral grafts by biological bonding of engineered cartilage tissues to bony scaffolds [PDF]

, 2010
In this study, we aimed at developing and validating a technique for the engineering of osteochondral grafts based on the biological bonding of a chondral layer with a bony scaffold by cell-laid extracellular matrix.
Barbero, Andrea, Bürgin, Vivienne, Candrian, Christian, Daniels, Alma U., Jakob, Marcel, Martin, Ivan, Schaefer, Dirk J., Scotti, Celeste, Valderrabano, Victor, Wirz, Dieter, Wolf, Francine   +10 more
core   +1 more source

Heterocycles in Peptidomimetics and Pseudopeptides: Design and Synthesis

Pharmaceuticals, 2012
This minireview provides a brief outline of the peculiar aspects of the preparation of peptidomimetic and pseudopeptidic structures containing heterocycles. In particular novel tricyclic structures are investigated as potential drugs.
Ambra Guarnaccio, Maria Funicello, Lucia Chiummiento, Iole Cerminara, Paolo Lupattelli   +4 more
doaj   +1 more source