Results 101 to 110 of about 512,987 (302)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Structure and thermomechanics of selective laser melted nickel-titanium [PDF]

, 2015
NiTi has been established for applications in load-bearing implants due to its mechanical properties, which mimic the characteristics of bone better than any other known biocompatible metal or metallic alloy.
Bormann, Anna Therese
core   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science
Regenerating bone defects has long been recognized as a significant clinical challenge. Drawing inspiration from the structure and properties of natural bone, bionic nanomaterials have emerged as a focal point in the field of bone tissue engineering ...
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
doaj   +1 more source

Novel Application Method for Mesenchymal Stem Cell Therapy Utilizing Its Attractant-Responsive Accumulation Property

Applied Sciences, 2019
Stem cell therapy is an emerging treatment modality for various diseases. Because mesenchymal stem cells (MSCs) are known to accumulate at the site of damage, their possible clinical application has been investigated.
Nobuyuki Ueda, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Akihiro Furuhashi, Ikue Narimatsu, Yuri Matsuura, Ryosuke Kondo, Yu Watanabe, Xiaoxu Zhang, Kiyoshi Koyano   +10 more
doaj   +1 more source

Functional scaffolding and self-scaffolding [PDF]

New Ideas in Psychology, 2005
Abstract Models of the nature of representation and cognition ground and constrain models of the construction of representation in learning and development: models of what is being constructed ground and constrain models of the processes of construction.
openaire   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Designing heterogeneous porous tissue scaffolds for additive manufacturing processes [PDF]

, 2013
A novel tissue scaffold design technique has been proposed with controllable heterogeneous architecture design suitable for additive manufacturing processes.
Khoda, AKM Bashirul, Koç, Bahattin, Özbolat, İbrahim T.   +2 more
core   +1 more source

A Vibrio cholerae viral satellite maximizes its spread and inhibits phage by remodeling hijacked phage coat proteins into small capsids

eLife
Phage satellites commonly remodel capsids they hijack from the phages they parasitize, but only a few mechanisms regulating the change in capsid size have been reported.
Caroline M Boyd, Sundharraman Subramanian, Drew T Dunham, Kristin N Parent, Kimberley D Seed   +4 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration

, 2021
Biomimetic bone tissue engineering strategies partially recapitulate development. We recently showed functional restoration of femoral defects using scaffold-free human mesenchymal stem cell (hMSC) condensates featuring localized morphogen presentation ...
Marsha W. Rolle, AD Dikina (11033001), Daniel S. Alt, Honghyun Park, Jung-Youn Shin, Yuxuan Cheng, Samuel Herberg, Phuong N. Dang, Daniel Varghai, Y Cheng (8477181), Eben Alsberg (10631045), Joel D. Boerckel, D Varghai (11032989), JY Shin (11032998), JD Boerckel (11033004), Anna D. Dikina, DS Alt (11032992), MW Rolle (11033007), Eben Alsberg, S Herberg (11032986), H Park (7811786), PN Dang (11032995)   +21 more
core   +1 more source