Results 81 to 90 of about 512,987 (302)
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Deliverable 2.2. - Fabrication and characterisation of 3D second generation scaffold.
, 2021 Realizzazione di uno scaffold per la rigenerazione del ...
Mariarosaria Bonetti +3 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Deep Scaffold Hopping with Multi-modal Transformer Neural Networks [PDF]
, 2020 Scaffold hopping, aiming to identify molecules with novel scaffolds but share a similar target biological activity toward known hit molecules, has always been a topic of interest in rational drug design.
Zengrong, Lei +5 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A NOVEL SCAFFOLD FOR GENERATION OF 3D TUMOR CONSTRUCTS [PDF]
, 2017 Cancer is the second most common cause of death in the United States, leading to over $440 million in annual funding for research and yet anticancer drug development is an unmet need.
Jalanti, Alison
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 2010 Poly(lactic acid) / Cellulose Nanocrystals (PLA / CNs) were simultaneously electrospun to fabricate a novel renewable and biocompatible nanocomposite as potential scaffold for bone tissue engineering.
Ramirez, Magaly Alexandra
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Drafting Liminalities: A Roundtable Discussion
On February 7, 2025, the Scaffold* editorial team brought together four scholars across built environment and visual disciplines to reflect on the volume theme of ‘drafting liminalities’. The public event, positioned as a discursive primer, was hosted at
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Regenerative TherapyIntroduction: Autologous cartilage transplantation has been applied clinically but its efficacy is limited by donor site morbidity, inter-donor variability, and high manufacturing costs. Primary chondrocytes also tend to dedifferentiate during expansion,
Yen-Chih Huang +11 more
doaj +1 more source