Results 61 to 70 of about 512,987 (302)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Low-temperature deposition manufacturing technology: a novel 3D printing method for bone scaffolds

Frontiers in Bioengineering and Biotechnology, 2023
The application of three-dimensional printing technology in the medical field has great potential for bone defect repair, especially personalized and biological repair. As a green manufacturing process that does not involve liquefication through heating,
Tianze Sun, Tianze Sun, Tianze Sun, Jinzuo Wang, Jinzuo Wang, Huagui Huang, Huagui Huang, Xin Liu, Xin Liu, Jing Zhang, Jing Zhang, Wentao Zhang, Wentao Zhang, Honghua Wang, Zhonghai Li, Zhonghai Li   +15 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Scaffold-Guided Crystallization of Oriented α‑FAPbI₃ Nanowire Arrays for Solar Cells

, 2023
Perovskite nanowire arrays with large surface areas for efficient charge transfer and continuous highly crystalline domains for efficient charge transport exhibit ideal morphologies for solar-cell active layers.
Sehee Jeong (1807378), Stephanie S. Lee (2000368), Claudia E. Avalos (2423293), Yichen Ma (6668426), Qintian Zhou (17426223), Thiago I. Rubio (17426220), Stefan Strauf (1580029), Seyed Sepehr Mohajerani (12518986), Aida Alaei (17426214), Ben Schmelmer (17426217), Min-Woo Kim (2819176), Justin Bendesky (17131461), Mia Klopfenstein (17426226)   +12 more
core   +1 more source

Emerging polymeric electrospun fibers: From structural diversity to application in flexible bioelectronics and tissue engineering

Exploration, 2022
Electrospinning (e‐spin) technique has emerged as a versatile and feasible pathway for constructing diverse polymeric fabric structures, which show potential applications in many biological and biomedical fields.
Xingyi Wan, Yunchao Zhao, Zhou Li, Linlin Li   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Scaffold-Assisted Ectopic Transplantation of Internal Organs and Patient-Derived Tumors

, 2019
Xenotransplantation of human tissues into immunodeficient mice has emerged as an invaluable preclinical model to study human biology and disease progression and predict clinical response.
Hye Jeong Oh (6530528), Hye Jeong Oh, Hoon Hur, Ryan Carpenter (7854539), In-Hye Ham (574983), Jungwoo Lee (433946), In-Hye Ham, Jungwoo Lee, Hoon Hur (574980), Daeyoung Kim, Ryan Carpenter, Daeyoung Kim (531188)   +11 more
core   +1 more source

The Role of Bioceramics for Bone Regeneration: History, Mechanisms, and Future Perspectives

Biomimetics
Osteoporosis is a skeletal disorder marked by compromised bone integrity, predisposing individuals, particularly older adults and postmenopausal women, to fractures.
Md Amit Hasan Tanvir, Md Abdul Khaleque, Ga-Hyun Kim, Whang-Yong Yoo, Young-Yul Kim   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source