Results 91 to 100 of about 579,989 (269)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

New Optical Splitter Design for Network Scalability and Flexibility [PDF]

open access: yes, 2009
In this paper, we present the design of two optical splitter which are 2x3 optical splitter-combine and Multi Ratio Optical Splitter (MROS) based on waveguide with SU-8 polymer material.
Syuhaimi, Mohammad
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Scalability Analysis of Programmable Metasurfaces for Beam Steering

open access: yesIEEE Access, 2020
Programmable metasurfaces have garnered significant attention as they confer unprecedented control over the electromagnetic (EM) response of any surface.
Hamidreza Taghvaee   +9 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Commentary by Tom Carey and Kevin Harrigan on Littlejohn, A. (2003) Reusing Online Resources, Chapter 9: Designing for Reuse and Versioning, by Mary Thorpe, Chris Kubiak and Keir Thorpe

open access: yesJournal of Interactive Media in Education, 2004
: This chapter presents some elegant ideas about how an individual institution can manage its online content to promote repurposing and re-use. The cases illustrate the benefits and issues involved in making this work.
Tom Carey, Kevin Harrigan
doaj   +1 more source

What is scalability? [PDF]

open access: yesACM SIGARCH Computer Architecture News, 1990
Scalability is a frequently-claimed attribute of multiprocessor systems. While the basic notion is intuitive, scalability has no generally-accepted definition. For this reason, current use of the term adds more to marketing potential than technical insight.In this paper, I first examine formal definitions of scalability, but
openaire   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

On The Case of Blockchain Adoption in the Internet of Things

open access: yesProceedings, 2018
Recently blockchain technology has been advocated as a solution fitting many different problems in several applicative fields; among these fields there is the Internet of Things (IoT) too.
Davide Pedrini   +3 more
doaj   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

open access: yes
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja   +8 more
wiley   +1 more source

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