Results 91 to 100 of about 1,777,748 (317)
Enhancing speed and scalability of the ParFlow simulation code
, 2017 Regional hydrology studies are often supported by high resolution simulations of subsurface flow that require expensive and extensive computations. Efficient usage of the latest high performance parallel computing systems becomes a necessity.
Burstedde, Carsten +2 more
core +1 more source
Proceedings of the VLDB Endowment, 2012 Over half a century old and showing no signs of aging, k -means remains one of the most popular data processing algorithms. As is well-known, a proper initialization of k -means is crucial for obtaining a good final solution.
Bahmani, Bahman +4 more
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
New Optical Splitter Design for Network Scalability and Flexibility [PDF]
, 2009 In this paper, we present the design of two optical splitter which are 2x3 optical splitter-combine and Multi Ratio Optical Splitter (MROS) based on waveguide with SU-8 polymer material.
Syuhaimi, Mohammad
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
ACM SIGARCH Computer Architecture News, 1990 Scalability is a frequently-claimed attribute of multiprocessor systems. While the basic notion is intuitive, scalability has no generally-accepted definition. For this reason, current use of the term adds more to marketing potential than technical insight.In this paper, I first examine formal definitions of scalability, but
openaire +1 more source
MLS: A Large-Scale Multilingual Dataset for Speech Research [PDF]
, 2020 Vineel Pratap +4 more
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The scalability of the matrices in direct Trefftz method in 2D Laplace problem
, 2015 This paper presents an interesting property of the matrices that may be obtained with the use of direct Trefftz method. It is proved analytically for 2D Laplace problem that values of the elements of matrices describing the capacitance of two scaled ...
Borkowski, M.
core +1 more source