Results 111 to 120 of about 590,813 (289)
e-Government – Assisting Reformed Public Administration in Romania [PDF]
Revista Romana de Economie, 2011 The adoption of web-based technologies in order to deliver government services has become a global trend in public administration. e-Government also means that governments have to act as a private entity and compete for best delivered services towards ...
Andreea GATMAN
doaj
Improving the Scalability of Multi-Agent Systems
, 2000 There is an increasing demand for designers and developers to construct ever larger multi-agent systems. Such systems will be composed of hundreds or even thousands of autonomous agents. Moreover, in open and dynamic environments, the number of agents in
Jennings, N. R., Turner, Phillip J.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
ISPRS International Journal of Geo-Information, 2019 Land cover mapping has benefited a lot from the introduction of the Geographic Object-Based Image Analysis (GEOBIA) paradigm, that allowed to move from a pixelwise analysis to a processing of elements with richer semantic content, namely objects or ...
François Merciol +8 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
IEEE AccessIn cloud computing and distributed databases, ensuring strong consistency and system reliability of the leader depends on distributed consensus algorithms such as Raft and Paxos.
Kiran Kumar Kondru, Saranya Rajiakodi
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
New Optical Splitter Design for Network Scalability and Flexibility [PDF]
, 2009 In this paper, we present the design of two optical splitter which are 2x3 optical splitter-combine and Multi Ratio Optical Splitter (MROS) based on waveguide with SU-8 polymer material.
Syuhaimi, Mohammad
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source