Results 91 to 100 of about 590,813 (289)

Enhancing speed and scalability of the ParFlow simulation code

open access: yes, 2017
Regional hydrology studies are often supported by high resolution simulations of subsurface flow that require expensive and extensive computations. Efficient usage of the latest high performance parallel computing systems becomes a necessity.
Burstedde, Carsten   +2 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Scalability Analysis of Programmable Metasurfaces for Beam Steering

open access: yesIEEE Access, 2020
Programmable metasurfaces have garnered significant attention as they confer unprecedented control over the electromagnetic (EM) response of any surface.
Hamidreza Taghvaee   +9 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Commentary by Tom Carey and Kevin Harrigan on Littlejohn, A. (2003) Reusing Online Resources, Chapter 9: Designing for Reuse and Versioning, by Mary Thorpe, Chris Kubiak and Keir Thorpe

open access: yesJournal of Interactive Media in Education, 2004
: This chapter presents some elegant ideas about how an individual institution can manage its online content to promote repurposing and re-use. The cases illustrate the benefits and issues involved in making this work.
Tom Carey, Kevin Harrigan
doaj   +1 more source

Distributed Denial of Service is a Scalability Problem

open access: yes, 2011
Distributed denial of service attacks are often considered a security problem. While this may be the way to view the problem with today's Internet, new network architectures attempting to address the issue should view it as a scalability problem.
Chung, Yoo
core   +1 more source

What is scalability? [PDF]

open access: yesACM SIGARCH Computer Architecture News, 1990
Scalability is a frequently-claimed attribute of multiprocessor systems. While the basic notion is intuitive, scalability has no generally-accepted definition. For this reason, current use of the term adds more to marketing potential than technical insight.In this paper, I first examine formal definitions of scalability, but
openaire   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

On The Case of Blockchain Adoption in the Internet of Things

open access: yesProceedings, 2018
Recently blockchain technology has been advocated as a solution fitting many different problems in several applicative fields; among these fields there is the Internet of Things (IoT) too.
Davide Pedrini   +3 more
doaj   +1 more source

Dynamic Organizations: Achieving Marketplace Agility Through Workforce Scalability [PDF]

open access: yes, 2006
Dynamic organizations (DOs) operate in business environments characterized by frequent and discontinuous change, They compete on the basis of marketplace agility; that is on their ability to generate a steady stream of both large and small innovations in
Dyer, Lee, Ericksen , Jeff
core   +1 more source

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