Results 101 to 110 of about 579,989 (269)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Dynamic Organizations: Achieving Marketplace Agility Through Workforce Scalability [PDF]
, 2006 Dynamic organizations (DOs) operate in business environments characterized by frequent and discontinuous change, They compete on the basis of marketplace agility; that is on their ability to generate a steady stream of both large and small innovations in
Dyer, Lee, Ericksen , Jeff
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A Heterogeneous Parallel Cholesky Block Factorization Algorithm
IEEE Access, 2018 As an essential part of current mainstream computing systems, GPUs are not only powerful graphics engines but also highly parallel programmable processors.
Rongteng Wu
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The scalability of the matrices in direct Trefftz method in 2D Laplace problem
, 2015 This paper presents an interesting property of the matrices that may be obtained with the use of direct Trefftz method. It is proved analytically for 2D Laplace problem that values of the elements of matrices describing the capacitance of two scaled ...
Borkowski, M.
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
How to Create Value(s) in the Sharing Economy: Business Models, Scalability, and Sustainability
Technology Innovation Management Review, 2019 By organizing peer-to-peer exchanges and promoting access over ownership, the sharing economy is transforming a great variety of sectors. Enjoying fast growth, the sharing economy is an umbrella term encompassing heterogeneous initiatives that create ...
Aurélien Acquier +2 more
doaj +1 more source
Domain Decomposition Based High Performance Parallel Computing\ud [PDF]
, 2009 The study deals with the parallelization of finite element based Navier-Stokes codes using domain decomposition and state-ofart sparse direct solvers. There has been significant improvement in the performance of sparse direct solvers.
Khaitan, Siddhartha +1 more
core +1 more source