Results 101 to 110 of about 1,696,641 (325)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

TO DISTRIBUTE THE ABNORMAL EVENT USING CM-DDS ALGORITHM, WITH SECURELY USING RSA-IVDE ALGORITHM

Jordanian Journal of Computers and Information Technology
Automating the secure distribution and storage of video data addresses inefficiencies in manual processes. The emphasis on secure distributed storage aligns with the increasing importance of safeguarding video data.
Kande Archana, V Kamakshi Prasad
doaj   +1 more source

Blockchain In Supply Chain Management Enhancing Traceability and Reducing Counterfeiting [PDF]

ITM Web of Conferences
Here is its sentence format:Blockchain in supply chain Blockchain technology can provide traceability, reduce counterfeiting, and improve overall process efficiency in your supply chain management. Yet obstacles, including but not limited to scalability,
Francis Sajo, G T Thiru Arooran, V Rajesh, B Manjusha, P Mathiyalagan, S Sivasubramaniyan   +5 more
doaj   +1 more source

Understanding and Comparing Scalable Gaussian Process Regression for Big Data

, 2018
As a non-parametric Bayesian model which produces informative predictive distribution, Gaussian process (GP) has been widely used in various fields, like regression, classification and optimization.
Cai, Jianfei, Liu, Haitao, Ong, Yew-Soon, Wang, Yi   +3 more
core   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Blockchain Technology in Supply Chain Management A Survey of Applications Challenges and Opportunities [PDF]

ITM Web of Conferences
Blockchain technology has become a disruptive force that is quickly reshaping supply chain management by providing greater transparency, security, and efficiency.
J Raja, D Ruba, V Sai Krishna, K Manasa, Tiwari Mohit, Koilraj Thomas   +5 more
doaj   +1 more source

Switching Mechanism and the Scalability of vertical-TFETs

, 2017
In this work, vertical tunnel field-effect transistors (v-TFETs) based on vertically stacked heretojunctions from 2D transition metal dichalcogenide (TMD) materials are studied by atomistic quantum transport simulations. The switching mechanism of v-TFET
Chen, Fan, Ilatikhameneh, Hesameddin, Klimeck, Gerhard, Rahman, Rajib, Tan, Yaohua   +4 more
core   +1 more source

Scalable freeform deformation [PDF]

ACM SIGGRAPH 2007 sketches, 2007
In this sketch, we propose a system for applying interactive deformation on large models. This system is based on two new algorithms performing (pre-)adaptive sampling and (post-)deformation on a geomtric stream, and allows to perform interactive deformation on arbitrary large models.
Boubekeur, Tamy, Sorkine, Olga, Schlick, Christophe   +2 more
openaire   +3 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Large-scale Reservoir Simulations on IBM Blue Gene/Q

, 2016
This paper presents our work on simulation of large-scale reservoir models on IBM Blue Gene/Q and studying the scalability of our parallel reservoir simulators. An in-house black oil simulator has been implemented.
H Liu, K Coats, K Coats, K Coats, K Coats, L Zhang, M Christie, Z Chen   +7 more
core   +1 more source