Results 111 to 120 of about 1,696,641 (325)
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Scalable Edge Partitioning [PDF]
, 2019 Edge-centric distributed computations have appeared as a recent technique to improve the shortcomings of think-like-a-vertex algorithms on large scale-free networks. In order to increase parallelism on this model, edge partitioning - partitioning edges into roughly equally sized blocks - has emerged as an alternative to traditional (node-based) graph ...
Schlag, Sebastian +3 more
openaire +3 more sources
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
, 2004 This report surveys different PKI technologies such as PKIX and SPKI and the issues of PKI that affect scalability. Much focus is spent on certificate revocation methodologies and status verification systems such as CRLs, Delta-CRLs, CRS, Certificate ...
Bonilla, Rafael, Slagell, Adam J
core +2 more sources
Dynamic Organizations: Achieving Marketplace Agility Through Workforce Scalability [PDF]
, 2006 Dynamic organizations (DOs) operate in business environments characterized by frequent and discontinuous change, They compete on the basis of marketplace agility; that is on their ability to generate a steady stream of both large and small innovations in
Dyer, Lee, Ericksen , Jeff
core +1 more source
Scalable interventions for refugees
Cambridge Prisms: Global Mental Health, 2023 Abstract Refugees experience a greater rate of common mental disorders relative to most other populations, and there remains a need to address these needs. However, most refugees are hosted in low-and-middle-income countries, where there is a lack of resources and mental health providers who can deliver mainstream mental health services.
openaire +3 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
The scalability of the matrices in direct Trefftz method in 2D Laplace problem
, 2015 This paper presents an interesting property of the matrices that may be obtained with the use of direct Trefftz method. It is proved analytically for 2D Laplace problem that values of the elements of matrices describing the capacitance of two scaled ...
Borkowski, M.
core +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Data Structures for Task-based Priority Scheduling
, 2013 Many task-parallel applications can benefit from attempting to execute tasks in a specific order, as for instance indicated by priorities associated with the tasks.
Cederman, Daniel +4 more
core +1 more source