Results 131 to 140 of about 1,777,748 (317)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

STOD: Towards Scalable Task-Oriented Dialogue System on MultiWOZ-API

Applied Sciences
Task-oriented dialogue systems (TODs) enable users to complete specific goals and are widely used in practice. Although existing models have achieved delightful performance for single-domain dialogues, scalability to new domains is far from well explored.
Hengtong Lu, Caixia Yuan, Xiaojie Wang
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A Study on Mechanization, Data, and Insurance Challenges for Agriculture Based on Hyperledger Fabric

IEEE Access
Agriculture is essential for human survival facing critical issues such as limited access to modern machinery, a lack of comprehensive data, and difficulties in implementing insurance programs.
Zhihua Hu, Bongjun Kim, Junho Jeong
doaj   +1 more source

Scalable breakthrough

Nature Nanotechnology, 2018
Ramya, Parameswaran, Bozhi, Tian
openaire   +3 more sources

Validation of the Spanish version of the Lawton IADL Scale for its application in elderly people [PDF]

, 2012
Itziar Vergara, Amaia Bilbao, Miren Orive, Susana García‐Gutiérrez, Gemma Navarro, José M. Quintana   +5 more
openalex   +1 more source

Gleaning insights from German energy transition and large-scale underground energy storage for China’s carbon neutrality

, 2023
Yachen Xie, Xuning Wu, Zhengmeng Hou, Zaoyuan Li, Jiashun Luo, Christian Truitt Lüddeke, Liangchao Huang, Lin Wu, Jianxing Liao   +8 more
openalex   +1 more source

MS-FRCNN: A Multi-Scale Faster RCNN Model for Small Target Forest Fire Detection [PDF]

, 2023
Lin Zhang, Mingyang Wang, Yunhong Ding, Xiangfeng Bu   +3 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A stochastic immersed boundary method for fluid-structure dynamics at microscopic length scales [PDF]

, 2007
Paul J. Atzberger, Peter R. Kramer, Charles S. Peskin   +2 more
openalex   +1 more source